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Table 3 Effect of B.orthobotrys on CFA induced arthritis in rats (n = 5, Mean ± SEM)

From: Anti-arthritic activity of aqueous-methanolic extract and various fractions of Berberis orthobotrys Bien ex Aitch

Treatments Increase in paw diameter (mm)
Day 1 Day 5 Day 10 Day 15
Arthritic Control
(3 ml/kg)
7.21 ± 0.035 16.22 ± 0.029 20.50 ± 0.024 23.72 ± 0.023
Normal Control 4.19 ± 0.160*** 4.24 ± 0.166*** 4.24 ± 0.097*** 4.27 ± 0.079***
Standard Aspirin (100 mg/kg) 5.90 ± 0.034***
(18.16)
7.29 ± 0.030***
(55.05)
6.34 ± 0.029***
(69.07)
5.83 ± 0.029***
(75.42)
Aqueous-methanolic extract (150 mg/kg) 5.13 ± 0.029***
(28.84)
6.63 ± 0.029***
(59.12)
5.69 ± 0.027***
(72.24)
4.51 ± 0.033***
(80.98)
n-butanol fraction
(150 mg/kg)
5.37 ± 0.030***
(25.52)
6.97 ± 0.033***
(57.02)
5.75 ± 0.029***
(71.95)
5.16 ± 0.032***
(78.24)
Ethyl acetate fraction
(150 mg/kg)
5.51 ± 0.030***
(23.57)
7.68 ± 0.044***
(52.65)
6.47 ± 0.032***
(68.43)
5.55 ± 0.039***
(76.60)
Aqueous fraction
(150 mg/kg)
5.82 ± 0.038***
(19.27)
8.22 ± 0.034***
(49.32)
6.95 ± 0.045***
(66.09)
6.02 ± 0.042***
(74.62)
  1. Values in the parenthesis represent percentage inhibition of paw edema. The statistical analysis was carried out using two way ANOVA followed by Bonferroni posttest. *** = p < 0.001 compared to arthritic control