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Table 3 Effect of B.orthobotrys on CFA induced arthritis in rats (n = 5, Mean ± SEM)

From: Anti-arthritic activity of aqueous-methanolic extract and various fractions of Berberis orthobotrys Bien ex Aitch

Treatments

Increase in paw diameter (mm)

Day 1

Day 5

Day 10

Day 15

Arthritic Control

(3 ml/kg)

7.21 ± 0.035

16.22 ± 0.029

20.50 ± 0.024

23.72 ± 0.023

Normal Control

4.19 ± 0.160***

4.24 ± 0.166***

4.24 ± 0.097***

4.27 ± 0.079***

Standard Aspirin (100 mg/kg)

5.90 ± 0.034***

(18.16)

7.29 ± 0.030***

(55.05)

6.34 ± 0.029***

(69.07)

5.83 ± 0.029***

(75.42)

Aqueous-methanolic extract (150 mg/kg)

5.13 ± 0.029***

(28.84)

6.63 ± 0.029***

(59.12)

5.69 ± 0.027***

(72.24)

4.51 ± 0.033***

(80.98)

n-butanol fraction

(150 mg/kg)

5.37 ± 0.030***

(25.52)

6.97 ± 0.033***

(57.02)

5.75 ± 0.029***

(71.95)

5.16 ± 0.032***

(78.24)

Ethyl acetate fraction

(150 mg/kg)

5.51 ± 0.030***

(23.57)

7.68 ± 0.044***

(52.65)

6.47 ± 0.032***

(68.43)

5.55 ± 0.039***

(76.60)

Aqueous fraction

(150 mg/kg)

5.82 ± 0.038***

(19.27)

8.22 ± 0.034***

(49.32)

6.95 ± 0.045***

(66.09)

6.02 ± 0.042***

(74.62)

  1. Values in the parenthesis represent percentage inhibition of paw edema. The statistical analysis was carried out using two way ANOVA followed by Bonferroni posttest. *** = p < 0.001 compared to arthritic control