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Table 2 Effect of B.orthobotrys on formaldehyde induced arthritis in rats (n = 5, Mean ± SEM)

From: Anti-arthritic activity of aqueous-methanolic extract and various fractions of Berberis orthobotrys Bien ex Aitch

Treatment groups Increase in paw diameter (mm)
Day 2 Day 4 Day 6 Day 8 Day 10
Arthritic control
(3 ml/kg)
8.49 ± 0.029 10.62 ± 0.023 12.56 ± 0.021 14.08 ± 0.020 16.92 ± 0.022
Standard Aspirin
(100 mg/kg)
4.61 ± 0.021***
(45.70)
4.95 ± 0.023***
(53.38)
4.07 ± 0.019***
(67.59)
3.77 ± 0.028***
(73.22)
3.63 ± 0.033***
(78.54)
Aqueous-methanolic extract (50 mg/kg) 4.76 ± 0.035***
(43.93)
5.35 ± 0.026***
(49.62)
4.41 ± 0.018***
(64.88)
4.12 ± 0.021***
(70.73)
4.09 ± 0.019***
(75.82)
Aqueous-methanolic extract (100 mg/kg) 4.51 ± 0.015***
(46.87)
4.93 ± 0.023***
(53.57)
4.10 ± 0.028***
(67.35)
3.72 ± 0.029***
(73.57)
3.60 ± 0.027***
(78.72)
Aqueous-methanolic extract (150 mg/kg) 4.28 ± 0.011***
(49.58)
4.63 ± 0.016***
(56.40)
3.63 ± 0.030***
(71.09)
3.28 ± 0.023***
(76.70)
3.03 ± 0.017***
(82.09)
n-butanol fraction
(50 mg/kg)
4.96 ± 0.019***
(41.57)
5.46 ± 0.020***
(48.58)
4.85 ± 0.025***
(61.38)
4.65 ± 0.024***
(66.97)
4.54 ± 0.027***
(73.16)
n-butanol fraction
(100 mg/kg)
4.68 ± 0.023***
(44.87)
5.11 ± 0.021***
(51.88)
4.41 ± 0.021***
(64.88)
4.13 ± 0.021***
(70.66)
4.02 ± 0.021***
(76.24)
n-butanol fraction
(150 mg/kg)
4.38 ± 0.026***
(48.40)
4.28 ± 0.020***
(59.69)
3.68 ± 0.023***
(70.70)
3.55 ± 0.021***
(74.78)
3.30 ± 0.023***
(80.49)
Ethyl acetate fraction
(50 mg/kg)
5.40 ± 0.033***
(36.39)
5.70 ± 0.022***
(46.32)
5.32 ± 0.030***
(57.64)
5.00 ± 0.021***
(64.48)
4.91 ± 0.022***
(70.98)
Ethyl acetate fraction
(100 mg/kg)
5.25 ± 0.021***
(38.16)
5.50 ± 0.021***
(48.21)
4.75 ± 0.017***
(62.18)
4.54 ± 0.022***
(67.75)
4.48 ± 0.022***
(73.52)
Ethyl acetate fraction
(150 mg/kg)
4.75 ± 0.020***
(44.05)
5.05 ± 0.017***
(52.44)
4.37 ± 0.024***
(65.20)
4.00 ± 0.021***
(71.59)
3.85 ± 0.022***
(77.24)
Aqueous fraction
(50 mg/kg)
5.88 ± 0.022***
(30.74)
6.13 ± 0.021***
(42.27)
5.71 ± 0.024***
(54.53)
5.37 ± 0.022***
(61.86)
5.25 ± 0.024***
(68.97)
Aqueous fraction
(100 mg/kg)
5.43 ± 0.024***
(36.04)
5.96 ± 0.030***
(43.87)
5.18 ± 0.027***
(58.75)
4.85 ± 0.028***
(65.55)
4.75 ± 0.027***
(71.92)
Aqueous fraction
(150 mg/kg)
4.98 ± 0.023***
(41.34)
5.58 ± 0.027***
(47.45)
4.47 ± 0.024***
(64.41)
4.25 ± 0.021***
(69.81)
4.20 ± 0.022***
(75.17)
  1. Values in the parenthesis represent percentage inhibition of paw edema. The statistical analysis was carried out using two way ANOVA followed by Bonferroni posttest. *** = P < 0.001 when compared to arthritic control