Table 2 Effect of B.orthobotrys on formaldehyde induced arthritis in rats (n = 5, Mean ± SEM)

Arthritic control

(3 ml/kg)

8.49 ± 0.029

10.62 ± 0.023

12.56 ± 0.021

14.08 ± 0.020

16.92 ± 0.022

Standard Aspirin

(100 mg/kg)

4.61 ± 0.021***

(45.70)

4.95 ± 0.023***

(53.38)

4.07 ± 0.019***

(67.59)

3.77 ± 0.028***

(73.22)

3.63 ± 0.033***

(78.54)

Aqueous-methanolic extract (50 mg/kg)

4.76 ± 0.035***

(43.93)

5.35 ± 0.026***

(49.62)

4.41 ± 0.018***

(64.88)

4.12 ± 0.021***

(70.73)

4.09 ± 0.019***

(75.82)

Aqueous-methanolic extract (100 mg/kg)

4.51 ± 0.015***

(46.87)

4.93 ± 0.023***

(53.57)

4.10 ± 0.028***

(67.35)

3.72 ± 0.029***

(73.57)

3.60 ± 0.027***

(78.72)

Aqueous-methanolic extract (150 mg/kg)

4.28 ± 0.011***

(49.58)

4.63 ± 0.016***

(56.40)

3.63 ± 0.030***

(71.09)

3.28 ± 0.023***

(76.70)

3.03 ± 0.017***

(82.09)

n-butanol fraction

(50 mg/kg)

4.96 ± 0.019***

(41.57)

5.46 ± 0.020***

(48.58)

4.85 ± 0.025***

(61.38)

4.65 ± 0.024***

(66.97)

4.54 ± 0.027***

(73.16)

n-butanol fraction

(100 mg/kg)

4.68 ± 0.023***

(44.87)

5.11 ± 0.021***

(51.88)

4.41 ± 0.021***

(64.88)

4.13 ± 0.021***

(70.66)

4.02 ± 0.021***

(76.24)

n-butanol fraction

(150 mg/kg)

4.38 ± 0.026***

(48.40)

4.28 ± 0.020***

(59.69)

3.68 ± 0.023***

(70.70)

3.55 ± 0.021***

(74.78)

3.30 ± 0.023***

(80.49)

Ethyl acetate fraction

(50 mg/kg)

5.40 ± 0.033***

(36.39)

5.70 ± 0.022***

(46.32)

5.32 ± 0.030***

(57.64)

5.00 ± 0.021***

(64.48)

4.91 ± 0.022***

(70.98)

Ethyl acetate fraction

(100 mg/kg)

5.25 ± 0.021***

(38.16)

5.50 ± 0.021***

(48.21)

4.75 ± 0.017***

(62.18)

4.54 ± 0.022***

(67.75)

4.48 ± 0.022***

(73.52)

Ethyl acetate fraction

(150 mg/kg)

4.75 ± 0.020***

(44.05)

5.05 ± 0.017***

(52.44)

4.37 ± 0.024***

(65.20)

4.00 ± 0.021***

(71.59)

3.85 ± 0.022***

(77.24)

Aqueous fraction

(50 mg/kg)

5.88 ± 0.022***

(30.74)

6.13 ± 0.021***

(42.27)

5.71 ± 0.024***

(54.53)

5.37 ± 0.022***

(61.86)

5.25 ± 0.024***

(68.97)

Aqueous fraction

(100 mg/kg)

5.43 ± 0.024***

(36.04)

5.96 ± 0.030***

(43.87)

5.18 ± 0.027***

(58.75)

4.85 ± 0.028***

(65.55)

4.75 ± 0.027***

(71.92)

Aqueous fraction

(150 mg/kg)

4.98 ± 0.023***

(41.34)

5.58 ± 0.027***

(47.45)

4.47 ± 0.024***

(64.41)

4.25 ± 0.021***

(69.81)

4.20 ± 0.022***

(75.17)