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Fig. 3 | BMC Complementary and Alternative Medicine

Fig. 3

From: Moringa isothiocyanate complexed with α-cyclodextrin: a new perspective in neuroblastoma treatment

Fig. 3

Inhibition of PI3K/Akt/mTOR and MAPK pathways in response to MAC in SH-SY5Y cells. Western blot analysis for pPI3K (a). CTR vs 1.0 μg ** p = 0.0017; CTR vs 2.5 μg *** p = 0,0001; CTR vs 5.0 μg **** p < 0.0001; 1.0 μg vs 5.0 μg * p = 0,0409. Western blot for pAKT (b). CTR vs 5.0 μg ** p = 0,0011; 1.0 μg vs 5.0 μg ** p = 0,0021; 2.5 μg vs 5.0 μg ** p = 0,0019. Western blot for pmTOR (c) CTR vs 2.5 μg ** p = 0.0017; CTR vs 5.0 μg **** p < 0.0001; 1.0 μg vs 2.5 μg *** p = 0,0005; 1.0 μg vs 5.0 μg **** p < 0.0001; 2.5 μg vs 5.0 μg *** p = 0,0002. Western blot analysis for pJNK (d). CTR vs 1.0 μg *** p = 0.0001; CTR vs 2.5 μg **** p < 0.0001; CTR vs 5.0 μg **** p < 0.0001; 1.0 μg vs 2.5 μg * p = 0,0122; 1.0 μg vs 5.0 μg * p = 0,0242. Western blot analysis for pp38 (E). CTR vs 1.0 μg **** p < 0.0001; CTR vs 2.5 μg **** p < 0.0001; CTR vs 5.0 μg **** p < 0.0001; 1.0 μg vs 5.0 μg **** p < 0.0001; 2.5 μg vs 5.0 μg **** p < 0.0001. Results were analyzed by one-way ANOVA followed by a Bonferroni test for multiple comparisons. Blots are representative of three separate and reproducible experiments. The statistical analysis was carried out on three repeated blots performed on separate experiments

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