Fig. 1

Study schedule of assessments. GCS, Glasgow coma Scale; NIHSS, National Institutes of Health Stroke Scale; mRS, Modified Rankin Scale; EQ-5D, EuroQol-5 Dimensions; MMSE, Mini-mental state examination; TOAST, Trial of Org 10,172 in Acute Stroke Treatment; ECG, Electrocardiograph. a. Visit 2 could be skipped if the patient is discharged at that time; b. optional items; c. It includes stroke, hypertension, diabetes, dyslipidemia, coronary heart disease, atrial fibrillation, carotid plaques, and tumors; d. MMSE is available for outpatient visits of visit 4; e. It includes body temperature, pulse, respiration and blood pressure, and body temperature should be collected at admission and 24 h after admission at visit 1; f. It includes examinations of blood routine test, blood glucose, blood lipids, liver and renal functions, myocardial enzymes, serum electrolytes, and coagulation function; g. It refers to the specific treatments for AIS, and the non-specific treatments will be recorded in the item “combined medications”; h. It is recorded from the time of obtaining the signed informed consent form to 30 days after the last administration; i. It refers to the direct costs, including the direct medical costs and the direct non-medical costs