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Fig. 7 | BMC Complementary and Alternative Medicine

Fig. 7

From: Xue-fu-Zhu-Yu decoction protects rats against retinal ischemia by downregulation of HIF-1α and VEGF via inhibition of RBP2 and PKM2

Fig. 7

The ratios of the mRNA concentrations of VEGF, HIF-1α, PKM2 and RBP2 relative to that of β-actin. Total mRNA was extracted from the sham retinas or the ischemic retinas pretreated with vehicle, a low dose XFZYD (1.35 g/Kg/day), a high dose XFZYD (2.7 g/kg/day), or posttreated with a high dose XFZUD. The mRNA concentration ratios of VEGF (a), HIF-1α (b), PKM2 (c) and RBP2 (d) relative to β-actin were calculated. The mean values ± SD (n = 4) was shown for each bar. ** (p < 0.01) represents significance (Sham vs. Vehicle + I/R). † (p < 0.05) or †† (p < 0.01) represents significance (Vehicle + I/R vs. XFZYD1.35 + I/R, XFZYD2.7 + I/R, or I/R + XFZYD2.7). VEGF: vascular endothelial growth factor, HIF-1α: hypoxia inducible factor 1α, PKM2: pyruvate kinase M2, RBP2: retinoblastoma-binding protein 2

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