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Fig. 5 | BMC Complementary and Alternative Medicine

Fig. 5

From: Xue-fu-Zhu-Yu decoction protects rats against retinal ischemia by downregulation of HIF-1α and VEGF via inhibition of RBP2 and PKM2

Fig. 5

Glial fibrillary acidic protein (GFAP, green) immunohistochemistry. a is the cellular nucleus of the sham retina labeled with 4,6-diamidine-2-phenylindole dihydrochloride (DAPI, blue); b shows Müller cells labelled with GFAP immunoreactivity at the end feet (arrow head) in the GCL and at the processes in the IPL, INL and ONL (arrows). c shows a retina that received I/R and preischemia adminstration of vehicle; there is an increase in anti-GFAP immuolabeling. (d, e, f) are sections from the retinas that received I/R and preischemia administration of 1.35 g/kg/day XFZYD (d, XFZYD1.35 + I/R), 2.7 g/kg/day XFZYD (e, XFZYD2.7 + I/R) or postischemia administration of 2.7 g/kg/day XFZYD (f, I/R + XFZYD2.7). Moreover, this ischemia-associated alteration was obviously and dose-dependently mitigated as ischemic retinas were preadministrated with 1.35 and 2.7 g/Kg/day XFZYD. Postischemia administration of 2.7 g/Kg/day XFZYD also obviously mitigated this ischemia-induced alteration. ONL: outer nuclear layer, OPL: outer plexiform layer, INL: inner nuclear layer, IPL: inner plexiform layer, GCL: ganglion cell layer. Scale bar = 50 μm

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