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Fig. 1 | BMC Complementary and Alternative Medicine

Fig. 1

From: Xue-fu-Zhu-Yu decoction protects rats against retinal ischemia by downregulation of HIF-1α and VEGF via inhibition of RBP2 and PKM2

Fig. 1

Electroretinogram (ERG): the influence of preischemia administration or postischemia administration of XFZYD on retinal ischemia. In comparison with the sham retina (Sham), the b-wave amplitude was considerably reduced after pressure-induced retinal ischemia plus reperfusion and preischemia administration (Vehicle + I/R; 1a) or postischemia administration of Vehicle (I/R + Vehicle; 1b) in a representative rat. This reduction was attenuated dose-dependently by preischemia administration (at 1.35 g/kg/day, XFZYD1.35 + I/R; at 2.7 g/kg/day, XFZYD2.7 + I/R, 1a) or postischemia administration of XFZYD (at 1.35 g/kg/day, I/R + XFZYD1.35; at 2.7 g/kg/day, I/R + XFZYD2.7, 1b) in one animal of each relevant group. As compared with the Sham group, a significant (**, p < 0.01) decrease in b-wave ratio was revealed for the Vehicle + I/R (1c) or I/R + Vehicle (1d) group following pressure-induced retinal ischemia. This ischemia-induced decrease was alleviated in a dose responsive and significant manner (†, p < 0.05; ††, p < 0.01, 1c) by the preischemia administration of 1.35 and 2.7 g/Kg/day of XFZYD. Postischemia administration of XFZYD at 2.7 g/Kg/day (1d) also significantly (††, p < 0.01) alleviated the reduction. The data are shown as mean values ± SD. XFZYD, Xue-Fu-Zhu-Yu decoction

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