Fig. 4

The protective effect of KIOM-MA-128 against the degeneration of tight junctions. We stained the ZO-1 protein expressed in the intestinal crypts, and our formula repressed the degradation of ZO-1 after DSS treatment (a). In tissue lysates, our formula attenuated the down-regulation of ZO-1 after DSS treatment (b). These western blot data represent the mean ± SEM values of each mouse in the same group. # p < 0.05 versus the control group, * p < 0.05 versus the DSS-treated group