Antibacterial activities and toxicological study of the aqueous extract from leaves of Alchornea cordifolia (Euphorbiaceae)

Merline Namekong Djimeli; Siméon Pierre Chegaing Fodouop; Guy Sedar Singor Njateng; Charles Fokunang; Donald Sedric Tala; Fabrice Kengni; Donatien Gatsing

doi:10.1186/s12906-017-1854-5

BMC Complementary Medicine and Therapies

Table 8 Effects of doses of aqueous extract from A.cordifolia on biochemical parameters after 2 weeks of administration to rats

From: Antibacterial activities and toxicological study of the aqueous extract from leaves of Alchornea cordifolia (Euphorbiaceae)

Studied Parameters	Doses
Studied Parameters	0- mg/kg	0i mg/kg	58 mg/kg	116 mg/kg	232 mg/kg
Serum Creatinine (mg/ dl)	2.64 ± 0.19^b	5.00 ± 0.92^a	2.31 ± 0.88^b	2.62 ± 1.15^b	2.65 ± 0.97^b
Urine Creatinine (mg/ dl)	25.35 ± 3.88^a	26.88 ± 2.28^a	25.85 ± 5.15^a	26.38 ± 3.64^a	28.09 ± 3.45^a
Total Cholesterol (mg/ dl)	288.89 ± 14.43^a	285.26 ± 11.47^a	329.38 ± 13.53^a	335.90 ± 12.31^a	340.72 ± 5.16^a
HDL Cholesterol (mg/dl)	58.60 ± 3.30^a	51.91 ± 4.36^a	65.21 ± 5.97^a	63.67 ± 3.87^a	62.50 ± 2.68^a
Atherosclerosis Index(mg/ dl)	3.98 ± 0.86^a	4.58 ± 0.55^a	4.51 ± 0.12^a	4.78 ± 0.74^a	4.55 ± 1.07^a
Triglycerides (mg/dl)	114.85 ± 7.09^a	102.46 ± 10.65^a	110.10 ± 7.92^a	119.64 ± 6.44^a	126.29 ± 5.94^a
Renal protein (mg/g)	3.81 ± 0.95^a	3.67 ± 1.11^a	3.72 ± 1.07^a	3.98 ± 1.02^a	4.02 ± 0.29^a
Spleen protein (mg/g)	72.73 ± 9.71^a	71.82 ± 8.40^a	75.55 ± 6.79^a	79.64 ± 9.58^a	84.36 ± 7.82^a
Pulmonary protein (mg/g)	59.09 ± 3.02^a	42.81 ± 2.22^b	40.97 ± 4.26^b	41.58 ± 4.21^b	45.36 ± 3.86^b
Hepatic protein (mg/g)	148.73 ± 2.70^ab	127.91 ± 12.18^b	134.82 ± 5.94^b	141.82 ± 6.31^ab	154.91 ± 13.08^a
Cardiac protein (mg/g)	53.94 ± 5.08a	40.03 ± 2.57b	42.73 ± 2.49ab	46.00 ± 6.08ab	49.45 ± 4.71ab
Serum protein (mg/g)	413.36 ± 19.7a	410.57 ± 12.60a	395.39 ± 14.57b	400.02 ± 17.01b	402.91 ± 10.58b
Urine protein (mg/g)	3.64 ± 0.94^a	3.24 ± 0.20^ab	2.80 ± 0.14^b	3.28 ± 0.21^ab	3.15 ± 0.32^ab
ALAT (UI/l)	30.36 ± 2.92^b	39.42 ± 3.51^a	34.86 ± 1.74^ab	41.92 ± 2.33^a	43.79 ± 2.44^a
ASAT (UI/l)	55.19 ± 3.18^a	51.90 ± 4.21^ab	49.02 ± 3.49^b	53.88 ± 4.34^ab	57.11 ± 4.33^a

0-: Normal control, 0i: Infected and non-treated. Tabulated values are mean ± SEM of five trials. Values of the same row with different letters are significantly different at P < 0.05

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