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Table 8 Effects of doses of aqueous extract from A.cordifolia on biochemical parameters after 2 weeks of administration to rats

From: Antibacterial activities and toxicological study of the aqueous extract from leaves of Alchornea cordifolia (Euphorbiaceae)

Studied Parameters

Doses

0- mg/kg

0i mg/kg

58 mg/kg

116 mg/kg

232 mg/kg

Serum Creatinine (mg/ dl)

2.64 ± 0.19b

5.00 ± 0.92a

2.31 ± 0.88b

2.62 ± 1.15b

2.65 ± 0.97b

Urine Creatinine (mg/ dl)

25.35 ± 3.88a

26.88 ± 2.28a

25.85 ± 5.15a

26.38 ± 3.64a

28.09 ± 3.45a

Total Cholesterol (mg/ dl)

288.89 ± 14.43a

285.26 ± 11.47a

329.38 ± 13.53a

335.90 ± 12.31a

340.72 ± 5.16a

HDL Cholesterol (mg/dl)

58.60 ± 3.30a

51.91 ± 4.36a

65.21 ± 5.97a

63.67 ± 3.87a

62.50 ± 2.68a

Atherosclerosis Index(mg/ dl)

3.98 ± 0.86a

4.58 ± 0.55a

4.51 ± 0.12a

4.78 ± 0.74a

4.55 ± 1.07a

Triglycerides (mg/dl)

114.85 ± 7.09a

102.46 ± 10.65a

110.10 ± 7.92a

119.64 ± 6.44a

126.29 ± 5.94a

Renal protein (mg/g)

3.81 ± 0.95a

3.67 ± 1.11a

3.72 ± 1.07a

3.98 ± 1.02a

4.02 ± 0.29a

Spleen protein (mg/g)

72.73 ± 9.71a

71.82 ± 8.40a

75.55 ± 6.79a

79.64 ± 9.58a

84.36 ± 7.82a

Pulmonary protein (mg/g)

59.09 ± 3.02a

42.81 ± 2.22b

40.97 ± 4.26b

41.58 ± 4.21b

45.36 ± 3.86b

Hepatic protein (mg/g)

148.73 ± 2.70ab

127.91 ± 12.18b

134.82 ± 5.94b

141.82 ± 6.31ab

154.91 ± 13.08a

Cardiac protein (mg/g)

53.94 ± 5.08a

40.03 ± 2.57b

42.73 ± 2.49ab

46.00 ± 6.08ab

49.45 ± 4.71ab

Serum protein (mg/g)

413.36 ± 19.7a

410.57 ± 12.60a

395.39 ± 14.57b

400.02 ± 17.01b

402.91 ± 10.58b

Urine protein (mg/g)

3.64 ± 0.94a

3.24 ± 0.20ab

2.80 ± 0.14b

3.28 ± 0.21ab

3.15 ± 0.32ab

ALAT (UI/l)

30.36 ± 2.92b

39.42 ± 3.51a

34.86 ± 1.74ab

41.92 ± 2.33a

43.79 ± 2.44a

ASAT (UI/l)

55.19 ± 3.18a

51.90 ± 4.21ab

49.02 ± 3.49b

53.88 ± 4.34ab

57.11 ± 4.33a

  1. 0-: Normal control, 0i: Infected and non-treated. Tabulated values are mean ± SEM of five trials. Values of the same row with different letters are significantly different at P < 0.05