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Table 2 Serum biochemical profiles of streptozotocin-nicotinamide-induced diabetic rats treated with various doses of the aqueous extract and whole formula powder of Mathurameha herbal formula

From: Hypoglycaemic activity of Mathurameha, a Thai traditional herbal formula aqueous extract, and its effect on biochemical profiles of streptozotocin-nicotinamide-induced diabetic rats

Treatment group (N = 5) Lipid profiles Liver functions Renal functions
CHOL (mg/dL) TG (mg/dL) ALP(U/L) ALT(U/L) AST(U/L) TP(g/dL) ALB(g/dL) GLO(g/dL) BUN(mg/dL) CREA(mg/dL) UA (mg/dL)
Normal control 96.80 ± 4.55b 93.40 ± 14.66 85.40 ± 14.71b 57.80 ± 9.73 122.40 ± 34.05 7.42 ± 0.24b 4.90 ± 0.10b 2.54 ± 0.18b 19.78 ± 1.80b 0.28 ± 0.04b 2.2 ± 0.56b
Diabetic control 119.20 ± 15.32a 138.00 ± 39.34 541.80 ± 167.86a 61.60 ± 19.59 106.60 ± 17.95 5.38 ± 0.33a 3.58 ± 0.30a 1.80 ± 0.14a 33.18 ± 5.88a 0.36 ± 0.05a 4.54 ± 2.15a
Glibenclamide 5 mg/kg 97.20 ± 23.51b 132.80 ± 32.52 388.00 ± 144.73a 52.00 ± 34.12 96.60 ± 50.28 5.00 ± 0.79a 3.56 ± 0.50a 1.42 ± 0.34a 30.76 ± 6.13a 0.28 ± 0.04b 2.48 ± 1.93b
Aqueous extract 12.5 mg/kg 125.25 ± 13.77a 197.00 ± 102.36a 289.00 ± 94.26b 62.00 ± 21.35 117.25 ± 34.51 6.98 ± 0.90b 4.78 ± 0.43b 2.25 ± 0.62 34.08 ± 8.04a 0.30 ± 0.08b 2.50 ± 0.93b
Aqueous extract 25 mg/kg 100.40 ± 5.98b 154.40 ± 43.17 315.40 ± 132.89ab 30.80 ± 14.91ab 84.40 ± 29.99 5.32 ± 0.59a 3.54 ± 0.23a 1.74 ± 0.38a 30.86 ± 5.42a 0.26 ± 0.05b 1.46 ± 0.34b
Aqueous extract 50 mg/kg 110.80 ± 21.66 168.00 ± 66.12a 384.40 ± 173.95a 43.80 ± 12.93 98.60 ± 30.78 6.04 ± 1.16a 4.02 ± 0.79a 1.98 ± 0.52a 33.82 ± 10.60a 0.26 ± 0.05b 2.34 ± 1.35b
Whole formula powder 87.5 mg/kg 112.50 ± 14.53a 181.25 ± 31.53a 413.00 ± 197.22a 41.00 ± 13.44 94.50 ± 49.68 6.10 ± 0.42a 4.20 ± 0.18ab 1.90 ± 0.34a 39.00 ± 13.26a 0.23 ± 0.05b 1.80 ± 0.80b
Whole formula powder 175 mg/kg 121.75 ± 20.85a 168.25 ± 67.37a 398.75 ± 208.32a 47.50 ± 11.73 109.25 ± 33.09 6.88 ± 1.24b 4.68 ± 0.51b 2.25 ± 0.69 37.38 ± 10.15a 0.33 ± 0.05b 2.55 ± 2.32b
Whole formula powder 350 mg/kg 119.00 ± 12.10 141.80 ± 33.49 465.80 ± 222.82a 48.60 ± 14.94 110.40 ± 25.86 5.92 ± 0.46a 4.16 ± 0.22a# 1.80 ± 0.31a 35.10 ± 4.25a 0.24 ± 0.05b 2.78 ± 1.20b
  1. Data were presented as a mean ± S.D.; CHOL total cholesterol, TG triglyceride, ALP alkaline phosphatase, ALT alanine transferase, AST aspartate transferase, TP total protein, ALB albumin, GLO globulin, BUN blood urea nitrogen, CREA creatinine, UA uric acid;
  2. aSignificant different from normal control, aSignificant different from diabetic control (p < 0.05; One-way ANOVA)