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Table 10 Effect of Cynara scolymus leaves extracts on SOD, CAT, GSH, MDA and AOPP levels in liver, pancreas and kidney of experimental groups of rats

From: Protective effects of Cynara scolymus leaves extract on metabolic disorders and oxidative stress in alloxan-diabetic rats

Groups SOD (U/mg protein) CAT (mmol H2O2/min/mg protein) GSH (mg/mg protein MDA (nmol MDA/mg protein) AOPP (nmol/mg protein)
Liver
 Control 75.62 ± 7.48 1.79 ± 1.34 33.88 ± 1.00 10.00 ± 5.25 0.20 ± 0.16
 Diab 55.21 ± 4.98* 0.63 ± 70.20* 13.41 ± 0.39*** 25.76 ± 1.21* 0.47 ± 0.05 **
 Diab + Ethanol extract of leaves C. scolymus (200 mg /kg) 72.14 ± 4.27 1.89 ± 0.56 ###£ 52.73 ± 9.82### 16.29 ± 5.59 ##££ 0.31 ± 0.17###£
 Diab + Ethanol extract of leaves C. scolymus (400 mg /kg) 64.85 ± 7.39 2.19 ± 0.20 ##£ 34.74 ± 2.49# 12.74 ± 7.85 0.26 ± 0.25 ##££
 Diab + Acarbose (12 mg/kg) 91.52 ± 1.58# 1.85 ± 1.91## 30.57 ± 2.46## 11.47 ± 6.63### 0.26 ± 0.22 ##
Pancreas
 Control 87.71 ± 3.58 1.25 ± 0.44 6.67 ± 1.93 9.21 ± 1.75 0.27 ± 0.14
 Diab 29.62 ± 2.23 *** 0.11 ± 0.82*** 2.01 ± 1.02* 23.91 ± 7.70** 0.63 ± 0.21*
 Diab + ethanol extract of C. scolymus (200 mg /kg) 64.43 ± 5.23 ##££ 1.16 ± 0.52 6.65 ± 3.69# 11.2 ± 17.26 0.19 ± 0.20
 Diab + ethanol extract of C. scolymus (200 mg /kg) 43.63 ± 1.06 #££ 0.89 ± 0.76 ##£ 5.96 ± 5.29# 17.56 ± 3.73 0.17 ± 0.15 ##££
 Diab + Acarbose (12 mg/kg) 55.15 ± 4.92## 0.78 ± 0.12 ### 2.46 ± 1.23## 16.71 ± 1.75# 0.31 ± 0.17#
Kidney
 Control 46.59 ± 5.10 2.08 ± 0.26 17.25 ± 3.97 21.22 ± 2.23 0.10 ± 0.04
 Diab 11.14 ± 3.70 * 0.60 ± 0.36*** 7.51 ± 0.29* 34.75 ± 1.23** 0.27 ± 0.04**
 Diab + ethanol extract of leaves C. scolymus (200 mg/kg) 18.23 ± 5.54 ##££ 2.02 ± 0.57 ##£ 20.07 ± 1.52# 16.03 ± 7.90##£ 0.11 ± 0.00 ###££
 Diab + ethanol extract of leaves C. scolymus (400 mg/kg) 21.66 ± 1.83# 1.28 ± 0.57 23.54 ± 8.72# 20.64 ± 1.40#£££ 0.12 ± 0.01 ##£
 Diab + Acarbose (12 mg/kg) 28.36 ± 1.67 ## 1.96 ± 0.47 ### 18.00 ± 0.87## 19.31 ± 6.50### 0.16 ± 0.02 ###
  1. Diabetic rats were orally administered with ethanol extract from leaves of C. scolymus and acarbose at the doses mentioned earlier for 28 days. Values are given as means ± SD (n = 8). * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001 were considered significant compared to control group; # p ≤ 0.05, ## p ≤ 0.001, ###p ≤ 0.001 were considered significant compared to diabetic rat.; £ p ≤ 0.05, ££ p ≤ 0.01 £££ p ≤ 0.001 compared to diabetic rats treated with acarbose