Fig. 4

Alterations of contents of Glu and Gln, and the Gln/Glu ratio in the hippocampi of mice by CUMS as well as XYS and FLU treatment. a Chromatograms of Glu. b Chromatograms of Gln. Results on references are shown on the left side, and results on hippocampal samples are shown on the right side. c The contents of Glu and Gln in the hippocampi were detected by LC-MS/MS. d The glutamate/glutamine ratio was calculated. Data were expressed as mean ± S.E.M,n = 5 per group.^∗ P < 0.05,^△△ P < 0.01,^# P < 0.001 vs. control; ^△ P < 0.05, ^## P < 0.001 vs. model