Modulatory influence of Acacia hydaspica R. Parker ethyl acetate extract against cisplatin inveigled hepatic injury and dyslipidemia in rats

Table 5 Effect of cisplatin (CP) and different treatments of AHE on liver tissue protein, H₂O₂, nitrite content and lipid peroxidation

Group	Protein (μg/mg Tissue)	H₂O₂ (nM/min/mg Tissue)	Nitrite (NO) (content μM/ml)	MDA (nM/min/mg protein)
Control	4.66 ± 0.05^b	1.97 ± 0.06^b	34.77 ± 1.32^b	3.5 ± 0.156^b
CP	1.19 ± 0.05^a	5.39 ± 0.256^a	90.41 ± 1.28^a	8.97 ± 0.337^a
AHE alone	4.67 ± 0.15^b	1.32 ± 0.06^b	36.24 ± 0.96^b	3.153 ± 0.087 ^b
CP + AHE	3.25 ± 0.13^a,b,d**	4.325 ± 0.198^a,b**,d	71.48 ± 1.86^a,b,d	6.11 ± 0.504^{a,b, d*}
AHE + CP	3.92 ± 0.04^{a,b, c}	2.38 ± 0.189^b,c	41.09 ± 0.69^a*,b,c	4.84 ± 0.06^a,b,c
CP + Sily	3.93 ± 0.11^a**,b	2.39 ± 0.037^b	40.98 ± 1.38^a*,b	4.90 ± 0.107^a*,b

Values expressed as mean ± SEM
^a Significance at p < 0.0001 Vs. control group
^b Significance at p < 0.0001 Vs. Cisplatin (CP) group
^c Significance at p < 0.0001 of AHE + CP pre-treated group Vs. CP + AHE post-treated group
^d Significance at p < 0.0001 of CP + AHE treatment groups Vs CP + Sily group
^*,** Significant difference at p < 0.001. Non-significant difference (p > 0.05) was recorded between control and AHE alone treated group in all parameters (One way ANOVA followed by Tukey’s multiple comparison tests)

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