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Table 5 Effect of cisplatin (CP) and different treatments of AHE on liver tissue protein, H2O2, nitrite content and lipid peroxidation

From: Modulatory influence of Acacia hydaspica R. Parker ethyl acetate extract against cisplatin inveigled hepatic injury and dyslipidemia in rats

Group Protein (μg/mg Tissue) H2O2 (nM/min/mg Tissue) Nitrite (NO) (content μM/ml) MDA (nM/min/mg protein)
Control 4.66 ± 0.05b 1.97 ± 0.06b 34.77 ± 1.32b 3.5 ± 0.156b
CP 1.19 ± 0.05a 5.39 ± 0.256a 90.41 ± 1.28a 8.97 ± 0.337a
AHE alone 4.67 ± 0.15b 1.32 ± 0.06b 36.24 ± 0.96b 3.153 ± 0.087 b
CP + AHE 3.25 ± 0.13a,b,d** 4.325 ± 0.198a,b**,d 71.48 ± 1.86a,b,d 6.11 ± 0.504a,b, d*
AHE + CP 3.92 ± 0.04a**,b, c** 2.38 ± 0.189b,c 41.09 ± 0.69a*,b,c 4.84 ± 0.06a*,b,c*
CP + Sily 3.93 ± 0.11a**,b 2.39 ± 0.037b 40.98 ± 1.38a*,b 4.90 ± 0.107a*,b
  1. Values expressed as mean ± SEM
  2. a Significance at p < 0.0001 Vs. control group
  3. b Significance at p < 0.0001 Vs. Cisplatin (CP) group
  4. c Significance at p < 0.0001 of AHE + CP pre-treated group Vs. CP + AHE post-treated group
  5. d Significance at p < 0.0001 of CP + AHE treatment groups Vs CP + Sily group
  6. *,** Significant difference at p < 0.001. Non-significant difference (p > 0.05) was recorded between control and AHE alone treated group in all parameters (One way ANOVA followed by Tukey’s multiple comparison tests)