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Table 6 Glucose and insulin concentrations obtained after the administration of an oral 3 g glucose load to diabetic rabbits (n = 6) treated with oral metformin (30 mg/kg) and Plantago ovata husk (300 mg/kg)

From: Influence of Plantago ovata husk (dietary fiber) on the bioavailability and other pharmacokinetic parameters of metformin in diabetic rabbits

Time (min)

Glucose (mg/dL)

Insulin (mUI/L)

Standard chow (group 3)

Supplemented chow (group 6)

p valuesa

Standard chow (group 3)

Supplemented chow (group 6)

p valuesa

0

457.7 ± 37.74

400.9 ± 79.04

0.133

0.936 ± 0.238

0.333 ± 0.070

0.000

30

528.7 ± 26.83

471.4 ± 52.61

0.039

1.773 ± 0.876

0.646 ± 0.169

0.011

60

573.0 ± 18.86

508.6 ± 81.48

0.089

3.579 ± 2.399

1.124 ± 0.652

0.036

120

543.0 ± 58.18

489.7 ± 66.09

0.102

1.517 ± 0.538

0.832 ± 0.397

0.031

180

530.2 ± 53.90

407.1 ± 58.62

0.004

1.075 ± 0.534

0.692 ± 0.333

0.167

  1. at Test