Influence of Plantago ovata husk (dietary fiber) on the bioavailability and other pharmacokinetic parameters of metformin in diabetic rabbits

Table 5 Non-compartmental pharmacokinetic parameters obtained for metformin (30 mg/kg) after its oral administration with Plantago ovata husk (300 mg/kg) to diabetic rabbits (n = 6)

Parameters	Standard chow		Supplemented chow		p values^a
Parameters	\( \overline{x} \) ± SD	CV (%)	\( \overline{x} \) ± SD	CV (%)	p values^a
λ (min⁻¹)	0.0039 ± 0.0010	25.17	0.0025 ± 0.0014	53.87	0.053^a
AUC (μg·min/mL)	1164.9 ± 262.1	22.50	1496.9 ± 438.9	29.32	0.160^a
C_max (μg/mL)	3.39 ± 0.290	8.53	3.12 ± 0.197	6.32	0.087^a
t_max (min)^c	110.0 ± 15.49	14.08	120.0 ± 0.00	-	0.138^b
Cl/F (mL/min/kg)	26.83 ± 5.81	21.67	21.65 ± 6.88	31.76	0.160^a
V_a/F (mL/kg)	7070.8 ± 884.9	12.52	9317.5 ± 1803.8	19.36	0.022^a
V_ss/F (mL/kg)	3891.2 ± 731.8	18.81	3080.4 ± 908.7	29.50	0.101^a
t_1/2λ (min)	189.6 ± 44.7	17.48	336.2 ± 152.6	45.40	0.052^a
AUMC (μg·min²/mL)	380,326.9 ± 158,923.7	41.79	827,234.6 ± 560,290.1	67.73	0.093^a
MRT (min)	145.9 ± 6.37	4.36	143.1 ± 4.07	2.84	0.409^a
MAT (min)	64.21		56.07
F (%)	36.73		41.52

^at Test
^bMann-Whitney Test
^csignificant differences with the value obtained when metformin was administered alone (Mann-Whitney Test)

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