Parameters
|
Standard chow
|
Supplemented chow
|
p values
|
---|
\( \overline{x} \) ± SD
|
CV (%)
|
\( \overline{x} \) ± SD
|
CV (%)
|
---|
λ (min−1)
|
0.0046 ± 0.0007
|
14.43
|
0.0029 ± 0.0011
|
39.32
|
0.014a
|
AUC (μg·min/mL)
|
960.6 ± 230.9
|
24.03
|
1296.2 ± 331.5
|
25.57
|
0.048a
|
Cmax (μg/mL)
|
3.23 ± 0.614
|
19.01
|
3.09 ± 0.425
|
13.77
|
0.694a
|
tmax (min)
|
90.0 ± 0.00
|
-
|
90.0 ± 0.00
|
-
|
1.000b
|
Cl/F (mL/min/kg)
|
32.70 ± 7.41
|
22.67
|
24.39 ± 5.99
|
24.55
|
0.062a
|
Va/F (mL/kg)
|
7374.6 ± 2253.7
|
30.56
|
9074.9 ± 2680.1
|
29.53
|
0.252a
|
Vss/F (mL/kg)
|
4416.9 ± 758.8
|
17.18
|
3445.3 ± 702.4
|
20.39
|
0.046a
|
t1/2λ (min)
|
155.3 ± 27.13
|
17.48
|
271.6 ± 100.9
|
37.13
|
0.014a
|
AUMC (μg·min2/mL)
|
245,796.4 ± 65,691.2
|
26.73
|
571,150.5 ± 320,022.7
|
56.03
|
0.015a
|
MRT (min)
|
136.6 ± 8.51
|
6.23
|
142.5 ± 6.52
|
14.50
|
0.199a
|
MAT (min)
|
54.95
| |
52.72
| | |
F (%)
|
30.29
| |
46.19
| | |
-
at Test; bMann-Whitney Test