Influence of Plantago ovata husk (dietary fiber) on the bioavailability and other pharmacokinetic parameters of metformin in diabetic rabbits

Table 3 Non-compartmental pharmacokinetic parameters obtained for metformin after its oral administration (30 mg/kg) to diabetic rabbits (n = 6)

Parameters	Standard chow		Supplemented chow		p values
Parameters	\( \overline{x} \) ± SD	CV (%)	\( \overline{x} \) ± SD	CV (%)	p values
λ (min⁻¹)	0.0046 ± 0.0007	14.43	0.0029 ± 0.0011	39.32	0.014^a
AUC (μg·min/mL)	960.6 ± 230.9	24.03	1296.2 ± 331.5	25.57	0.048^a
C_max (μg/mL)	3.23 ± 0.614	19.01	3.09 ± 0.425	13.77	0.694^a
t_max (min)	90.0 ± 0.00	-	90.0 ± 0.00	-	1.000^b
Cl/F (mL/min/kg)	32.70 ± 7.41	22.67	24.39 ± 5.99	24.55	0.062^a
V_a/F (mL/kg)	7374.6 ± 2253.7	30.56	9074.9 ± 2680.1	29.53	0.252^a
V_ss/F (mL/kg)	4416.9 ± 758.8	17.18	3445.3 ± 702.4	20.39	0.046^a
t_1/2λ (min)	155.3 ± 27.13	17.48	271.6 ± 100.9	37.13	0.014^a
AUMC (μg·min²/mL)	245,796.4 ± 65,691.2	26.73	571,150.5 ± 320,022.7	56.03	0.015^a
MRT (min)	136.6 ± 8.51	6.23	142.5 ± 6.52	14.50	0.199^a
MAT (min)	54.95		52.72
F (%)	30.29		46.19