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Table 2 Glucose and insulin concentrations obtained after the administration of an oral 3 g glucose load to diabetic rabbits (n = 6) treated with an intravenous metformin dose of 30 mg/kg

From: Influence of Plantago ovata husk (dietary fiber) on the bioavailability and other pharmacokinetic parameters of metformin in diabetic rabbits

Time (min)

Glucose (mg/dL)

Insulin (mUI/L)

Standard chow (group 1)

Supplemented chow (group 4)

p values a

Standard chow (group 1)

Supplemented chow (group 4)

p valuesa

0

399.9 ± 81.72

375.7 ± 152.0

0.737

0.616 ± 0.561

0.801 ± 0.464

0.547

30

461.6 ± 28.41

446.9 ± 154.2

0.824

0.990 ± 0.779

1.227 ± 0.814

0.617

60

496.4 ± 46.99

497.0 ± 122.1

0.991

1.297 ± 0.853

1.718 ± 1.202

0.500

120

552.3 ± 39.15

497.4 ± 102.5

0.248

1.000 ± 0.274

1.892 ± 1.186

0.103

180

471.7 ± 81.52

457.6 ± 117.4

0.814

0.573 ± 0.238

1.432 ± 0.940

0.055

  1. at Test