Influence of Plantago ovata husk (dietary fiber) on the bioavailability and other pharmacokinetic parameters of metformin in diabetic rabbits

Table 1 Non-compartmental pharmacokinetic parameters obtained for metformin after its intravenous administration (30 mg/kg) to diabetic rabbits (n = 6)

Parameters	Standard chow		Supplemented chow		p values
Parameters	\( \overline{x} \) ± SD	CV (%)	\( \overline{x} \) ± SD	CV (%)	p values
λ (min⁻¹)	0.0022 ± 0.0011	50.04	0.0028 ± 0.0008	28.78	0.233^a
AUC (μg·min/mL)	3171.9 ± 680.4	21.45	2806.1 ± 471.9	16.82	0.351^a
Cl (mL/min/kg)	9.86 ± 2.29	23.20	10.99 ± 2.14	19.47	0.351^a
V_a (mL/kg)	5137.7 ± 1839.9	35.81	4301.6 ± 1786.6	41.53	0.382^a
V_ss (mL/kg)	3829.3 ± 1483.7	38.74	3279.1 ± 1174.1	35.81	0.487^a
t_1/2λ (min)	385.9 ± 47.71	47.71	268.5 ± 85.4	31.80	0.220^a
AUMC (μg·min²/mL)	1,411,571.6 ± 915,944.8	64.89	847,182.9 ± 324,044.5	38.25	0.279^a
MRT (min)	81.70 ± 3.98	4.87	89.81 ± 13.02	14.50	0.198^a

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