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Table 6 Anthelmintic activity of aerial part of Isodon rugosus against Pheretima posthuma and Ascaridia galli

From: Demonstration of biological activities of extracts from Isodon rugosus Wall. Ex Benth: Separation and identification of bioactive phytoconstituents by GC-MS analysis in the ethyl acetate extract

Samples Concentration (mg/ml) Pheretima posthuma Ascaridia galli
Paralysis time in Minutes (mean ± SD) Death time in Minutes (mean ± SD) Paralysis time in Minutes (mean ± SD) Death time in Minutes (mean ± SD)
Ir.Cr 10 24.33 ± 1.15*** 67.00 ± 2.00*** 20.25 ± 0.57*** 69.39 ± 0.60***
20 18.67 ± 1.53** 60.00 ± 2.00*** 17.01 ± 0.46*** 61.18 ± 0.67***
40 11.33 ± 1.56ns 40.67 ± 1.53*** 13.48 ± 0.52*** 53.19 ± 0.36***
Ir.Hex 10 23.33 ± 2.08*** 67.33 ± 2.08*** 28.89 ± 0.52*** 87.34 ± 0.78***
20 17.00 ± 1.00* 62.33 ± 1.53*** 17.32 ± 0.96*** 71.36 ± 0.56***
40 11.67 ± 1.53ns 49.00 ± 1.00*** 3.43 ± 0.67** 56.63 ± 0.38***
Ir.Cf 10 14.00 ± 1.00ns 50.00 ± 1.00ns 14.53 ± 0.67ns 53.01 ± 0.44***
20 10.00 ± 2.00ns 37.67 ± 1.53ns 11.95 ± 0.34ns 41.77 ± 0.40ns
40 7.33 ± 1.53ns 30.67 ± 2.52ns 9.85 ± 0.50ns 34.39 ± 0.55ns
Ir.EtAc 10 18.00 ± 2.00ns 52.00 ± 2.00ns 18.13 ± 0.49*** 58.37 ± 1.16***
20 13.00 ± 2.00ns 45.00 ± 2.00* 13.63 ± 0.40** 49.31 ± 0.82***
40 10.00 ± 2.00ns 38.67 ± 1.53** 10.29 ± 0.56* 42.25 ± 0.89***
Ir.Aq 10 21.00 ± 2.00** 61.00 ± 2.00*** 19.66 ± 0.88*** 68.54 ± 0.81***
20 19.00 ± 2.00** 56.00 ± 2.00*** 15.4 ± 0.61*** 57.15 ± 0.85***
40 15.00 ± 2.00** 47.67 ± 1.53*** 13.40 ± 0.69*** 52.85 ± 0.50***
Ir.Sp 10 13.33 ± 1.53ns 44.00 ± 2.00ns 8.40 ± 0.9*** 43.00 ± 1.00**
20 9.00 ± 2.00ns 33.67 ± 3.05ns 8.33 ± 0.58ns 32.79 ± 0.54***
40 5.67 ± 1.53ns 27.67 ± 1.53ns 4.33 ± 0.58ns 29.22 ± 0.61**
Albendazole 10 12.33 ± 2.08 48.67 ± 1.53 13.10 ± 1.85 47.40 ± 1.50
20 10.33 ± 2.57 37.33 ± 1.53 9.80 ± 1.60 40.20 ± 2.25
40 7.00 ± 2.00 28.67 ± 1.53 7.10 ± 1.01 33.60 ± 1.76
Negative control ----- ----- ----- ----- ------
  1. Values significantly different (*: P < 0.05, ** P < 0.01 and *** P < 0.001) as compared to positive control drug. ns: Non significantly different in comparion to control group
  2. Keys:
  3. Ir.Cr Crude methanolic extract, Ir.Hex n-hexane fraction, Ir.Cf Chloroform fraction, Ir.EtAc Ethyl acetate fraction, Ir.Aq Aqueous fraction, Ir.Sp Saponins.