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Table 3 Effect of C. swynnertonii ethanolic stem bark extract on spleen

From: In vivo effect of Commiphora swynnertonii ethanolic extracts on Trypanosoma congolense and selected immunological components in mice

Treatments White pulp Red pulp
Perioarteriolar lymphoid sheath (PALS) Lymphoid follicles Marginal zone
PBSG (0.1 ml/10 g) Normal Normal Normal Congestion
TME, 500 mg/kg No change No change No change Congestion
SE, 500 mg/kg No change No change No change Congestion
TME, 1500 mg/kg No change Marked reduction in cellularity and size, Apoptosis, pyknosis of lymphocytes and tingible body macrophage Depleted Cellularity and size severely reduced
SE, 1500 mg/kg Apoptosis, white foci of variable sizes -Apoptosis,
-white foci of variable sizes, pyknosis of lymphocytes is evident in some of the foci.
-Severely reduced in size
No change Apoptosis, white foci of variable sizes
Infected, treated with 1500 mg/kg of extract but died on 3rd day Apoptosis and white foci of variable size -Apoptosis characterized by white foci and pyknosis of lymphocytes A moderate widening Congestion
Infected, treated with 2000 mg/kg of extract but died on 2nd day No change -Moderate apoptosis characterized with karyorrhexis of lymphocytes
-Increased in size
A moderate widening No change
Infected but not treated, died on 9th day post inoculation No change Severely reduced No change Increased cellularity and size