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Table 3 Antiviral activities of phenanthrenes from Bletilla striata in MDCK cells

From: Antiviral activity of phenanthrenes from the medicinal plant Bletilla striata against influenza A virus

Compound CC50 Simultaneous treatment Post-treatment
  (μM)a IC50 (μM)b SIc IC50 (μM)b SIc
1 200.8 ± 18.6 - - - -
2 67.9 ± 13.1 28.6 ± 4.3 2.3 31.4 ± 2.1 2.2
3 50.3 ± 6.2 20.4 ± 3.2 2.5 22.6 ± 1.8 2.2
4 80.0 ± 20.1 14.6 ± 2.4 5.5 18.4 ± 3.1 4.3
5 96.8 ± 15.6 - - - -
6 106.4 ± 21.2 33.8 ± 2.7 3.1 37.3 ± 3.2 2.8
7 129.5 ± 15.6 28.5 ± 2.8 4.5 31.2 ± 2.2 4.1
8 110.6 ± 17.3 - - - -
9 160.3 ± 20.4 - - - -
10 141.6 ± 25.0 43.3 ± 5.3 3.3 42.3 ± 3.9 3.4
11 118.6 ± 19.6 38.6 ± 2.9 3.1 35.2 ± 3.7 3.4
12 115.7 ± 16.8 - - - -
Oseltamivir 598.8 ± 62.1 4.9 ± 0.9 122.2 0.9 ± 0.2 665.3
  1. aCC50: 50% cytotoxic concentration
  2. bIC50: 50% inhibitory concentration
  3. cSI: selective index; CC50mean/IC50mean
  4. -: The results showed that antiviral effects against A/Sydney/5/97(H3N2) were less than 50% inhibition
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