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Table 8 Effects of EOM and 5-FU on hematological parameters of peripheral blood of mice (n = 6) subjected to different treatments (9 days)

From: Toxicity and antitumor potential of Mesosphaerum sidifolium (Lamiaceae) oil and fenchone, its major component

Parameters

Healthy animals

Tumor control

5-FU

EOM

   

25 mg/kg

50 mg/kg

100 mg/kg

150 mg/kg

Red blood cells, 106/mm3

9.3 ± 0.1

5.8 ± 0.4b

9.7 ± 0.2a

6.9 ± 0.1

8.1 ± 0.2a

9.0 ± 0.3a

Hemoglobin, g/dL

14.8 ± 0.2

9.4 ± 0.6b

14.9 ± 0.4a

10.2 ± 0.7

13.4 ± 0.3a

14.7 ± 0.7a

Hematocrit, %

43.8 ± 0.5

29.0 ± 1.8b

46.6 ± 1.0a

40.0 ± 1.6a

43.8 ± 1.4a

44.2 ± 2.1a

MCV, fm3

46.6 ± 1.0

49.8 ± 0.6

49.0 ± 0.6

57.6 ± 2.2a,b

55.6 ± 1.0a,b

48.8 ± 0.6

MCH, pg

15.8 ± 0.5

16.0 ± 0.1

15.4 ± 0.2

14.8 ± 1.1

17.0 ± 0.2

16.2 ± 0.3

MCHC, g/dL

33.7 ± 0.3

34.5 ± 0.8

31.3 ± 0.2

25.7 ± 1.6a,b

30.7 ± 0.3

33.2 ± 0.6

Total leukocytes, 103/mm3

8.1 ± 0.4

15.1 ± 1.1b

3.2 ± 0.1a

29.8 ± 8.7a,b

3.1 ± 0.4a

5.0 ± 1.6a

Lymphocytes, %

60.6 ± 4.2

52.4 ± 12.7

90.4 ± 0.9a

43.6 ± 9.4

56.6 ± 2.1

51.2 ± 11.9

Neutrophils, %

34.6 ± 4.2

45.4 ± 12.4

7.0 ± 0.7a

46.6 ± 8.8

35.6 ± 2.9

47.4 ± 13.9

Monocytes, %

4.4 ± 0.7

2.0 ± 0.5

2.6 ± 0.7

4.0 ± 0.6

2.4 ± 0.5

3.4 ± 0.4

Eosinophils, %

0.4 ± 0.2

0.2 ± 0.2

0.0 ± 0.2

0.2 ± 0.2

0.0 ± 0.0

0.0 ± 0.0

  1. Data are presented as mean ± SEM of six animals analyzed by ANOVA followed by Tukey test. a p < 0.05 compared to tumor control; b p < 0.05 compared to healthy animals by ANOVA followed by Tukey