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Table 8 Effects of EOM and 5-FU on hematological parameters of peripheral blood of mice (n = 6) subjected to different treatments (9 days)

From: Toxicity and antitumor potential of Mesosphaerum sidifolium (Lamiaceae) oil and fenchone, its major component

Parameters Healthy animals Tumor control 5-FU EOM
    25 mg/kg 50 mg/kg 100 mg/kg 150 mg/kg
Red blood cells, 106/mm3 9.3 ± 0.1 5.8 ± 0.4b 9.7 ± 0.2a 6.9 ± 0.1 8.1 ± 0.2a 9.0 ± 0.3a
Hemoglobin, g/dL 14.8 ± 0.2 9.4 ± 0.6b 14.9 ± 0.4a 10.2 ± 0.7 13.4 ± 0.3a 14.7 ± 0.7a
Hematocrit, % 43.8 ± 0.5 29.0 ± 1.8b 46.6 ± 1.0a 40.0 ± 1.6a 43.8 ± 1.4a 44.2 ± 2.1a
MCV, fm3 46.6 ± 1.0 49.8 ± 0.6 49.0 ± 0.6 57.6 ± 2.2a,b 55.6 ± 1.0a,b 48.8 ± 0.6
MCH, pg 15.8 ± 0.5 16.0 ± 0.1 15.4 ± 0.2 14.8 ± 1.1 17.0 ± 0.2 16.2 ± 0.3
MCHC, g/dL 33.7 ± 0.3 34.5 ± 0.8 31.3 ± 0.2 25.7 ± 1.6a,b 30.7 ± 0.3 33.2 ± 0.6
Total leukocytes, 103/mm3 8.1 ± 0.4 15.1 ± 1.1b 3.2 ± 0.1a 29.8 ± 8.7a,b 3.1 ± 0.4a 5.0 ± 1.6a
Lymphocytes, % 60.6 ± 4.2 52.4 ± 12.7 90.4 ± 0.9a 43.6 ± 9.4 56.6 ± 2.1 51.2 ± 11.9
Neutrophils, % 34.6 ± 4.2 45.4 ± 12.4 7.0 ± 0.7a 46.6 ± 8.8 35.6 ± 2.9 47.4 ± 13.9
Monocytes, % 4.4 ± 0.7 2.0 ± 0.5 2.6 ± 0.7 4.0 ± 0.6 2.4 ± 0.5 3.4 ± 0.4
Eosinophils, % 0.4 ± 0.2 0.2 ± 0.2 0.0 ± 0.2 0.2 ± 0.2 0.0 ± 0.0 0.0 ± 0.0
  1. Data are presented as mean ± SEM of six animals analyzed by ANOVA followed by Tukey test. a p < 0.05 compared to tumor control; b p < 0.05 compared to healthy animals by ANOVA followed by Tukey