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Table 6 Effects of EOM, fenchone and 5-FU in the mice organ indices (n = 6) subjected to different treatments (9 days)

From: Toxicity and antitumor potential of Mesosphaerum sidifolium (Lamiaceae) oil and fenchone, its major component

Groups

Dose, mg/kg

Heart index, mg/g

Liver index, mg/g

Kidneys index, mg/g

Thymus index, mg/g

Spleen index, mg/g

Healthy animals

-

4.2 ± 0.3

50.8 ± 2.0

10.9 ± 0.5

3.7 ± 0.5

5.5 ± 0.5

Tumor control

-

3.5 ± 0.2

71.2 ± 3.1b

10.6 ± 0.3

2.5 ± 0.2

5.7 ± 0.7

5-FU

25

4.8 ± 0.5

57.4 ± 1.9a

12.3 ± 0.3

2.9 ± 0.0

6.3 ± 0.5

EOM

50

3.2 ± 0.5

59.3 ± 2.9 a

9.0 ± 0.7

2.6 ± 0.6

6.5 ± 1.6

EOM

100

4.0 ± 0.1

55.8 ± 1.6a

11.5 ± 0.4

3.6 ± 0.4

7.1 ± 0.4

EOM

150

4.2 ± 0.2

56.8 ± 3.0a

11.6 ± 0.9

2.4 ± 0.2

7.4 ± 1.2

Fenchone

30

4.0 ± 0,2

71.4 ± 6.3b

11.0 ± 0.7

4.1 ± 0.2a,c

8.9 ± 1.3

Fenchone

60

4.7 ± 0.4a

75.6 ± 1.4b,c

13.4 ± 1.0

3.5 ± 0.3

7.9 ± 0.7

  1. Data presented as mean ± SEM of six animals analyzed by ANOVA followed by Tukey test. a p < 0.05 compared to tumor control. b p<0.05 compared to healthy animals. c p<0,05 compared to 25 mg/kg 5-FU group by ANOVA followed by Tukey