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Table 6 Effects of EOM, fenchone and 5-FU in the mice organ indices (n = 6) subjected to different treatments (9 days)

From: Toxicity and antitumor potential of Mesosphaerum sidifolium (Lamiaceae) oil and fenchone, its major component

Groups Dose, mg/kg Heart index, mg/g Liver index, mg/g Kidneys index, mg/g Thymus index, mg/g Spleen index, mg/g
Healthy animals - 4.2 ± 0.3 50.8 ± 2.0 10.9 ± 0.5 3.7 ± 0.5 5.5 ± 0.5
Tumor control - 3.5 ± 0.2 71.2 ± 3.1b 10.6 ± 0.3 2.5 ± 0.2 5.7 ± 0.7
5-FU 25 4.8 ± 0.5 57.4 ± 1.9a 12.3 ± 0.3 2.9 ± 0.0 6.3 ± 0.5
EOM 50 3.2 ± 0.5 59.3 ± 2.9 a 9.0 ± 0.7 2.6 ± 0.6 6.5 ± 1.6
EOM 100 4.0 ± 0.1 55.8 ± 1.6a 11.5 ± 0.4 3.6 ± 0.4 7.1 ± 0.4
EOM 150 4.2 ± 0.2 56.8 ± 3.0a 11.6 ± 0.9 2.4 ± 0.2 7.4 ± 1.2
Fenchone 30 4.0 ± 0,2 71.4 ± 6.3b 11.0 ± 0.7 4.1 ± 0.2a,c 8.9 ± 1.3
Fenchone 60 4.7 ± 0.4a 75.6 ± 1.4b,c 13.4 ± 1.0 3.5 ± 0.3 7.9 ± 0.7
  1. Data presented as mean ± SEM of six animals analyzed by ANOVA followed by Tukey test. a p < 0.05 compared to tumor control. b p<0.05 compared to healthy animals. c p<0,05 compared to 25 mg/kg 5-FU group by ANOVA followed by Tukey