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Table 4 Effects of EOM, fenchone and 5-FU on tumor volume, weight, and total viable cancer cells in mice (n=6) transplanted with Ehrlich ascites carcinoma cells subjected to different treatments (9 days)

From: Toxicity and antitumor potential of Mesosphaerum sidifolium (Lamiaceae) oil and fenchone, its major component

Groups

Dose, mg/kg

Tumor volume, mL

Tumor weight, g

Total viable cancer cells, ×107

Tumor Control

-

7.6 ± 0.6

11.9 ± 0.9

339.8 ± 46.4

5-FU

25

0.1 ± 0.0a

2.3 ± 1.0a

8.5 ± 2.3a

EOM

50

4.9 ± 2.2

12.1 ± 1.3

120.1 ± 18.9

EOM

100

0.0 ± 0.0a

0.8 ± 0.4a

4.4 ± 1.8a

EOM

150

0.0 ± 0.0a

1.3 ± 0.2a

6.9 ± 4.1a

Fenchone

30

5.5 ± 1.0

8.4 ± 1.0

228.0 ± 39.9

Fenchone

60

0.8 ± 0.6a

3.9 ± 0.9a

10.9 ± 4.1a

  1. Data presented as mean ± SEM of six animals analyzed by ANOVA followed by Tukey test. a p  <  0.05 compared to tumor control