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Table 4 Effects of EOM, fenchone and 5-FU on tumor volume, weight, and total viable cancer cells in mice (n=6) transplanted with Ehrlich ascites carcinoma cells subjected to different treatments (9 days)

From: Toxicity and antitumor potential of Mesosphaerum sidifolium (Lamiaceae) oil and fenchone, its major component

Groups Dose, mg/kg Tumor volume, mL Tumor weight, g Total viable cancer cells, ×107
Tumor Control - 7.6 ± 0.6 11.9 ± 0.9 339.8 ± 46.4
5-FU 25 0.1 ± 0.0a 2.3 ± 1.0a 8.5 ± 2.3a
EOM 50 4.9 ± 2.2 12.1 ± 1.3 120.1 ± 18.9
EOM 100 0.0 ± 0.0a 0.8 ± 0.4a 4.4 ± 1.8a
EOM 150 0.0 ± 0.0a 1.3 ± 0.2a 6.9 ± 4.1a
Fenchone 30 5.5 ± 1.0 8.4 ± 1.0 228.0 ± 39.9
Fenchone 60 0.8 ± 0.6a 3.9 ± 0.9a 10.9 ± 4.1a
  1. Data presented as mean ± SEM of six animals analyzed by ANOVA followed by Tukey test. a p  <  0.05 compared to tumor control