Fig. 7

Combination effects of SbE and cisplatin on mRNA expression levels of p53, p21, Bax, DRAM, Beclin 1, Atg5, and Atg12 in CRC. After cells were exposed 200 ~ 400 μg/mL of SbE and 30 μM of cisplatin for 24 h, mRNA expression levels of (a) p53, p21, Bax, DRAM, (b) HDAC1, (c) Beclin 1, Atg5, and Atg12 in CRC were quantified by qPCR. All mRNA expression levels were normalized against TBP. Each value is the mean ± SD. p < 0.05 was taken to define statistical significance. One-way ANOVA followed by Duncan post hoc test. Cis; 30 μM of cisplatin