Evaluation of anti-inflammatory and gastric anti-ulcer activity of Phyllanthus niruri L. (Euphorbiaceae) leaves in experimental rats

Table 2 Anti-inflammatory effect of Phyllanthus niruri methanolic extract on carrageenan induced changes in paw thickness in experimental rats

Groups	NC	CC	IP-20	MEPN-100	MEPN-200	MEPN-400
Dose mg/kg	---------	-------	20 mg/kg ibuprofen	100 mg/kg extract	200 mg/kg extract	400 mg/kg extract
Initial paw thickness (cm)	0.49 ± 0.07	0.42 ± 0.06	0.45 ± 0.09^b*	0.44 ± 0.05^b*	0.44 ± 0.08^b*	0.43 ± 0.06^b*
Paw thickness (cm) after 1 h	0.49 ± 0.05	0.74 ± 0.08^a*	0.52 ± 0.07^b*	0.6 ± 0.07^b,c	0.58 ± 0.05^b,c	0.51 ± 0.07^b*
Paw thickness (cm) after 2 h	0.49 ± 0.08	0.83 ± 0.07^a**	0.57 ± 0.05^b**	0.67 ± 0.04^b,c	0.63 ± 0.05^b*	0.57 ± 0.06 ^b**
Paw thickness (cm) after 3 h	0.49 ± 0.05	0.91 ± 0.09^a**	0.62 ± 0.10^b**	0.7 ± 0.06^b,c	0.66 ± 0.06^b*	0.6 ± 0.08^b**
Paw thickness (cm) after 4 h	0.49 ± 0.06	0.99 ± 0.11^a**	0.58 ± 0.10^b**	0.68 ± 0.09^b*	0.62 ± 0.07^b**	0.56 ± 0.09 ^b**
Paw thickness (cm) after 5 h	0.49 ± 0.08	0.96 ± 0.09^a**	0.49 ± 0.07^b**	0.65 ± 0.10^b*	0.59 ± 0.07^b**	0.48 ± 0.06 ^b**
Paw thickness (cm) after 6 h	0.48 ± 0.06	0.94 ± 0.07^a**	0.33 ± 0.09^b**	0.50 ± 0.06^b**	0.42 ± 0.07^b**	0.29 ± 0.07 ^b**

Each value is Mean ± S.E.M (n = 6). (*) indicates statistically significant difference from respective group using one way analysis of variance, followed by Dunnett’s multiple comparison test (*p < 0.05 and ^** p < 0.01). ^cindicates statistically no significant difference from respective group using one way analysis of variance, followed by Dunnett’s multiple comparison test (p > 0.05). ^awhen compared with normal control, ^bwhen compared with carrageenan control; NC- Normal control, CC- Carrageenan control, IP-20 – ibuprofen 20 mg/kg/day, MEPN-100 -methanolic extract of P. niruri 100 mg/kg/day, MEPN-200- methanolic extract of P. niruri 200 mg/kg/day, MEPN-400 - methanolic extract of P. niruri 400 mg/kg/day.

ISSN: 2662-7671