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Table 2 Anti-inflammatory effect of Phyllanthus niruri methanolic extract on carrageenan induced changes in paw thickness in experimental rats

From: Evaluation of anti-inflammatory and gastric anti-ulcer activity of Phyllanthus niruri L. (Euphorbiaceae) leaves in experimental rats

Groups NC CC IP-20 MEPN-100 MEPN-200 MEPN-400
Dose mg/kg --------- ------- 20 mg/kg ibuprofen 100 mg/kg extract 200 mg/kg extract 400 mg/kg extract
Initial paw thickness (cm) 0.49 ± 0.07 0.42 ± 0.06 0.45 ± 0.09b* 0.44 ± 0.05b* 0.44 ± 0.08b* 0.43 ± 0.06b*
Paw thickness (cm) after 1 h 0.49 ± 0.05 0.74 ± 0.08a* 0.52 ± 0.07b* 0.6 ± 0.07b,c 0.58 ± 0.05b,c 0.51 ± 0.07b*
Paw thickness (cm) after 2 h 0.49 ± 0.08 0.83 ± 0.07a** 0.57 ± 0.05b** 0.67 ± 0.04b,c 0.63 ± 0.05b* 0.57 ± 0.06 b**
Paw thickness (cm) after 3 h 0.49 ± 0.05 0.91 ± 0.09a** 0.62 ± 0.10b** 0.7 ± 0.06b,c 0.66 ± 0.06b* 0.6 ± 0.08b**
Paw thickness (cm) after 4 h 0.49 ± 0.06 0.99 ± 0.11a** 0.58 ± 0.10b** 0.68 ± 0.09b* 0.62 ± 0.07b** 0.56 ± 0.09 b**
Paw thickness (cm) after 5 h 0.49 ± 0.08 0.96 ± 0.09a** 0.49 ± 0.07b** 0.65 ± 0.10b* 0.59 ± 0.07b** 0.48 ± 0.06 b**
Paw thickness (cm) after 6 h 0.48 ± 0.06 0.94 ± 0.07a** 0.33 ± 0.09b** 0.50 ± 0.06b** 0.42 ± 0.07b** 0.29 ± 0.07 b**
  1. Each value is Mean ± S.E.M (n = 6). (*) indicates statistically significant difference from respective group using one way analysis of variance, followed by Dunnett’s multiple comparison test (*p < 0.05 and ** p < 0.01). cindicates statistically no significant difference from respective group using one way analysis of variance, followed by Dunnett’s multiple comparison test (p > 0.05). awhen compared with normal control, bwhen compared with carrageenan control; NC- Normal control, CC- Carrageenan control, IP-20 – ibuprofen 20 mg/kg/day, MEPN-100 -methanolic extract of P. niruri 100 mg/kg/day, MEPN-200- methanolic extract of P. niruri 200 mg/kg/day, MEPN-400 - methanolic extract of P. niruri 400 mg/kg/day.