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Table 7 ROC Curve of Lipid Peroxide, Oxidized Glutathione, Reduced Glutathione, Glutathione S-transferase together with GSH/GSSG ratio between neuro-intoxicated, protected and therapeutically treated rat pups compared to healthy control

From: Postnatal treatment using curcumin supplements to amend the damage in VPA-induced rodent models of autism

Parameters Groups Area under the curve Cutoff value Sensitivity % Specificity %
LPO (U\ml) VPA 0.545 3.250 90.0% 50.0%
VPA-CUR 0.915 2.650 80.0% 100.0%
CUR 0.805 3.150 80.0% 70.0%
GSH (mmol/L) VPA 1.000 200.350 100.0% 100.0%
VPA-CUR 1.000 210.320 100.0% 100.0%
CUR 0.570 278.195 40.0% 90.0%
GSSG (pg/ml) VPA 1.000 137.500 100.0% 100.0%
VPA-CUR 1.000 175.000 100.0% 100.0%
CUR 0.935 117.500 90.0% 90.0%
GSH (pg\ml) VPA 1.000 6260.938 100.0% 100.0%
VPA-CUR 1.000 6572.500 100.0% 100.0%
CUR 0.570 8693.594 40.0% 90.0%
GSH + GSSG VPA 1.000 6435.938 100.0% 100.0%
VPA-CUR 1.000 6762.500 100.0% 100.0%
CUR 0.580 8798.594 40.0% 90.0%
GSH/GSSG VPA 1.000 45.417 100.0% 100.0%
VPA-CUR 1.000 40.685 100.0% 100.0%
CUR 0.900 71.255 90.0% 80.0%