Postnatal treatment using curcumin supplements to amend the damage in VPA-induced rodent models of autism

Al-Askar, Maha; Bhat, Ramesa Shafi; Selim, Manar; Al-Ayadhi, Laila; El-Ansary, Afaf

doi:10.1186/s12906-017-1763-7

BMC Complementary Medicine and Therapies

Table 4 Pearson Correlations between the measured parameters

From: Postnatal treatment using curcumin supplements to amend the damage in VPA-induced rodent models of autism

Parameters	R (Person Correlation)	Sig.
Started weight (g) ~ Final weight (g)	0.641^**	0.001	P^a
Started weight (g) ~ Weight Gained	0.494^**	0.001	P^a
Started weight (g) ~ Brain weight (g)	0.652^**	0.001	P^a
Started weight (g) ~ Opening eyes after (Days)	0.313^*	0.049	P^a
Started weight (g) ~ Glutamate/Glutamin Ratio	0.322^*	0.043	P^a
Started weight (g) ~ GSH (mmol/L)	−0.438^**	0.005	N^b
Started weight (g) ~ GSSG (pg/ml)	0.765^**	0.001	P^a
Started weight (g) ~ GSH (pg\ml)	−0.438^**	0.005	N^b
Started weight (g) ~ GSH + GSSG	-0.408^**	0.009	N^b
Started weight (g) ~ GSH/GSSG	-0.479^**	0.002	N^b
Final weight (g) ~ Weight Gained	0.984^**	0.001	P^a
Final weight (g) ~ Brain weight (g)	0.887^**	0.001	P^a
Final weight (g) ~ LPO (U\ml)	−0.371^*	0.019	N^b
Final weight (g) ~ GSSG (pg/ml)	0.390^*	0.013	P^a
Weight Gained ~ Brain weight (g)	0.853^**	0.001	P^a
Weight Gained ~ LPO (U\ml)	−0.353^*	0.025	N^b
Brain weight (g) ~ LPO (U\ml)	−0.313^*	0.049	N^b
Brain weight (g) ~ GSSG (pg/ml)	0.369^*	0.019	P^a
Opening eyes after (Days) ~ GSH (mmol/L)	−0.326^*	0.04	N^b
Opening eyes after (Days) ~ GSH (pg\ml)	−0.326^*	0.04	N^b
Opening eyes after (Days) ~ GSH + GSSG	-0.322^*	0.043	N^b
IL-6 (pg\ml) ~ Glutamin (pmol\ml)	0.377^*	0.017	P^a
IL-6 (pg\ml) ~ Glutamate (nmol\ml)	0.322^*	0.043	P^a
IL-6 (pg\ml) ~ LPO (U\ml)	0.318^*	0.045	P^a
IFN-g (pg\ml) ~ GSTs (mU\ml)	0.588^**	0.001	P^a
IFN-g (pg\ml) ~ Glutamin (pmol\ml)	0.541^**	0.001	P^a
IFN-g (pg\ml) ~ Glutamate (nmol\ml)	0.502^**	0.001	P^a
IFN-g (pg\ml) ~ LPO (U\ml)	0.523^**	0.001	P^a
CYP450 (ng\ml) ~ GSTs (mU\ml)	−0.347^*	0.028	N^b
5HT (ng\ml) ~ GSSG (pg/ml)	−0.352^*	0.026	N^b
GSTs (mU\ml) ~ Glutamin (pmol\ml)	0.597^**	0.001	P^a
GSTs (mU\ml) ~ Glutamate (nmol\ml)	0.451^**	0.004	P^a
GSTs (mU\ml) ~ LPO (U\ml)	0.650^**	0.001	P^a
Glutamin (pmol\ml) ~ Glutamate (nmol\ml)	0.635^**	0.001	P^a
Glutamin (pmol\ml) ~ Glutamate/Glutamin Ratio	−0.414^**	0.008	N^b
Glutamin (pmol\ml) ~ LPO (U\ml)	0.722^**	0.001	P^a
Glutamate (nmol\ml) ~ Glutamate/Glutamin Ratio	0.435^**	0.005	P^a
Glutamate (nmol\ml) ~ LPO (U\ml)	0.678^**	0.001	P^a
Glutamate/Glutamin Ratio ~ GSSG (pg/ml)	0.337^*	0.033	P^a
GSH (mmol/L) ~ GSSG (pg/ml)	−0.684^**	0.001	N^b
GSH (mmol/L) ~ GSH (pg\ml)	1.000^**	0.001	P^a
GSH (mmol/L) ~ GSH + GSSG	0.999^**	0.001	P^a
GSH (mmol/L) ~ GSH/GSSG	0.819^**	0.001	P^a
GSSG (pg/ml) ~ GSH (pg\ml)	−0.684^**	0.001	N^b
GSSG (pg/ml) ~ GSH + GSSG	-0.651^**	0.001	N^b
GSSG (pg/ml) ~ GSH/GSSG	-0.816^**	0.001	N^b
GSH (pg\ml) ~ GSH + GSSG	0.999^**	0.001	P^a
GSH (pg\ml) ~ GSH/GSSG	0.819^**	0.001	P^a
GSH + GSSG ~ GSH/GSSG	0.803^**	0.001	P^a

**Correlation is significant at the 0.01 level.
*Correlation is significant at the 0.05 level.
^aPositive Correlation.
^bNegative Correlation

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ISSN: 2662-7671

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