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Table 3 Mean ± S.D. together with the independent t-test for Lipid Peroxide, Oxidized Glutathione, Reduced Glutathione, Glutathione S-transferase together with GSH/GSSG ratio between neuro -intoxicated, protected and therapeutically treated rat pups compared to healthy control

From: Postnatal treatment using curcumin supplements to amend the damage in VPA-induced rodent models of autism

Parameter Group N Min Max Mean ± S.D. Percent Change P valuea P valueb
LPO (U\ml) Control 10 2.70 5.00 3.68 ± 0.84 100.00   0.001
VPA 10 3.10 3.90 3.52 ± 0.24 95.65 0.573
VPA-CUR 10 1.40 3.40 2.46 ± 0.55c 66.73 0.001
CUR 10 1.40 3.70 2.56 ± 0.82c 69.57 0.007
GSSG (pg/ml) Control 10 65.00 125.00 92.50 ± 23.24 100.00   0.001
VPA 10 150.00 310.00 225.00 ± 51.91c 243.24 0.001
VPA-CUR 10 225.00 460.00 345.00 ± 81.99c 372.97 0.001
CUR 10 100.00 180.00 138.50 ± 21.48 149.73 0.001
GSH (pg\ml) Control 10 7104.06 9134.06 8016.97 ± 638.64 100.00   0.001
VPA 10 3506.25 5417.81 4397.66 ± 557.53c 54.85 0.001
VPA-CUR 10 4419.06 6040.94 5099.31 ± 485.93c 63.61 0.001
CUR 10 6825.00 9638.75 8190.53 ± 948.88 102.16 0.637
GSTs (mU\ml) Control 10 8.50 20.50 15.35 ± 3.98 100.00   0.001
VPA 10 11.60 18.40 13.84 ± 2.00 90.19 0.304
VPA-CUR 10 8.50 17.00 12.74 ± 2.74 83.00 0.105
CUR 10 5.50 17.00 11.57 ± 3.78c 75.37 0.043
GSH/GSSG Control 10 59.15 140.52 92.59 ± 27.69 100.00   0.001
VPA 10 13.87 31.68 20.54 ± 5.53c 22.19 0.001
VPA-CUR 10 9.61 22.22 15.64 ± 4.24c 16.89 0.001
CUR 10 47.43 87.58 60.33 ± 11.63c 65.16 0.005
  1. a P value between control group and other groups
  2. b P value between all groups
  3. cIndicates there is significant difference between the group and control at 0.05 level