Postnatal treatment using curcumin supplements to amend the damage in VPA-induced rodent models of autism

Table 3 Mean ± S.D. together with the independent t-test for Lipid Peroxide, Oxidized Glutathione, Reduced Glutathione, Glutathione S-transferase together with GSH/GSSG ratio between neuro -intoxicated, protected and therapeutically treated rat pups compared to healthy control

Parameter	Group	N	Min	Max	Mean ± S.D.	Percent Change	P value^a	P value^b
LPO (U\ml)	Control	10	2.70	5.00	3.68 ± 0.84	100.00		0.001
	VPA	10	3.10	3.90	3.52 ± 0.24	95.65	0.573
	VPA-CUR	10	1.40	3.40	2.46 ± 0.55^c	66.73	0.001
	CUR	10	1.40	3.70	2.56 ± 0.82^c	69.57	0.007
GSSG (pg/ml)	Control	10	65.00	125.00	92.50 ± 23.24	100.00		0.001
	VPA	10	150.00	310.00	225.00 ± 51.91^c	243.24	0.001
	VPA-CUR	10	225.00	460.00	345.00 ± 81.99^c	372.97	0.001
	CUR	10	100.00	180.00	138.50 ± 21.48	149.73	0.001
GSH (pg\ml)	Control	10	7104.06	9134.06	8016.97 ± 638.64	100.00		0.001
	VPA	10	3506.25	5417.81	4397.66 ± 557.53^c	54.85	0.001
	VPA-CUR	10	4419.06	6040.94	5099.31 ± 485.93^c	63.61	0.001
	CUR	10	6825.00	9638.75	8190.53 ± 948.88	102.16	0.637
GSTs (mU\ml)	Control	10	8.50	20.50	15.35 ± 3.98	100.00		0.001
	VPA	10	11.60	18.40	13.84 ± 2.00	90.19	0.304
	VPA-CUR	10	8.50	17.00	12.74 ± 2.74	83.00	0.105
	CUR	10	5.50	17.00	11.57 ± 3.78^c	75.37	0.043
GSH/GSSG	Control	10	59.15	140.52	92.59 ± 27.69	100.00		0.001
	VPA	10	13.87	31.68	20.54 ± 5.53^c	22.19	0.001
	VPA-CUR	10	9.61	22.22	15.64 ± 4.24^c	16.89	0.001
	CUR	10	47.43	87.58	60.33 ± 11.63^c	65.16	0.005

^a P value between control group and other groups
^b P value between all groups
^cIndicates there is significant difference between the group and control at 0.05 level

ISSN: 2662-7671