Postnatal treatment using curcumin supplements to amend the damage in VPA-induced rodent models of autism

Table 1 Mean ± S.D. together with the independent t-test for weight gain, brain weight and age of eye opening between neurointoxicated, protected and therapeutically treated rat pups compared to healthy control

Parameter	Group	N	Min	Max	Mean ± S.D.	Percent Change	P value^a	P value^b
Started weight (g)	Control	10	14.80	20.00	17.62 ± 1.96	100.00
	VPA	10	14.90	18.80	17.47 ± 1.38	99.15	0.845	0.001
	VPA-CUR	10	24.50	31.70	27.81 ± 2.82^c	157.83	0.001
	CUR	10	15.20	18.20	16.46 ± 1.04	93.42	0.121
Final weight (g)	Control	10	26.10	78.90	58.42 ± 21.45	100.00		0.001
	VPA	10	17.20	75.40	42.21 ± 27.85	72.25	0.163
	VPA-CUR	10	69.30	100.30	88.18 ± 12.10^c	150.94	0.002
	CUR	10	55.60	70.00	63.22 ± 5.61	108.22	0.509
Weight Gained	Control	10	11.30	58.90	40.80 ± 19.56	100.00		0.001
	VPA	10	-0.30	60.30	24.74 ± 28.56	60.64	0.162
	VPA-CUR	10	44.80	72.90	60.37 ± 9.80^c	147.97	0.014
	CUR	10	40.40	51.80	46.76 ± 4.80	114.61	0.371
Brain weight (g)	Control	10	1.17	1.61	1.38 ± 0.15	100.00
	VPA	10	1.12	1.63	1.31 ± 0.17	95.08	0.361	0.001
	VPA-CUR	10	1.51	1.72	1.61 ± 0.06^c	116.54	0.001
	CUR	10	1.29	1.59	1.43 ± 0.09	103.58	0.377
Opening eyes (Days)	Control	10	15.00	16.00	15.30 ± 0.48	100.00		0.001
	VPA	10	10.00	17.00	14.50 ± 3.21	94.77	0.454
	VPA-CUR	10	14.00	16.00	15.20 ± 1.03	99.35	0.786
	CUR	10	11.00	13.00	12.0 0.47^c	78.43	0.001

^a P value between control group and other groups
^b P value between all groups
^cIndicates there is significant difference between the group and control at 0.05 level.

ISSN: 2662-7671