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Table 1 Mean ± S.D. together with the independent t-test for weight gain, brain weight and age of eye opening between neurointoxicated, protected and therapeutically treated rat pups compared to healthy control

From: Postnatal treatment using curcumin supplements to amend the damage in VPA-induced rodent models of autism

Parameter Group N Min Max Mean ± S.D. Percent Change P valuea P valueb
Started weight (g) Control 10 14.80 20.00 17.62 ± 1.96 100.00   
VPA 10 14.90 18.80 17.47 ± 1.38 99.15 0.845 0.001
VPA-CUR 10 24.50 31.70 27.81 ± 2.82c 157.83 0.001
CUR 10 15.20 18.20 16.46 ± 1.04 93.42 0.121
Final weight (g) Control 10 26.10 78.90 58.42 ± 21.45 100.00   0.001
VPA 10 17.20 75.40 42.21 ± 27.85 72.25 0.163
VPA-CUR 10 69.30 100.30 88.18 ± 12.10c 150.94 0.002
CUR 10 55.60 70.00 63.22 ± 5.61 108.22 0.509
Weight Gained Control 10 11.30 58.90 40.80 ± 19.56 100.00   0.001
VPA 10 -0.30 60.30 24.74 ± 28.56 60.64 0.162
VPA-CUR 10 44.80 72.90 60.37 ± 9.80c 147.97 0.014
CUR 10 40.40 51.80 46.76 ± 4.80 114.61 0.371
Brain weight (g) Control 10 1.17 1.61 1.38 ± 0.15 100.00   
VPA 10 1.12 1.63 1.31 ± 0.17 95.08 0.361 0.001
VPA-CUR 10 1.51 1.72 1.61 ± 0.06c 116.54 0.001
CUR 10 1.29 1.59 1.43 ± 0.09 103.58 0.377
Opening eyes (Days) Control 10 15.00 16.00 15.30 ± 0.48 100.00   0.001
VPA 10 10.00 17.00 14.50 ± 3.21 94.77 0.454
VPA-CUR 10 14.00 16.00 15.20 ± 1.03 99.35 0.786
CUR 10 11.00 13.00 12.0 0.47c 78.43 0.001
  1. a P value between control group and other groups
  2. b P value between all groups
  3. cIndicates there is significant difference between the group and control at 0.05 level.