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Table 1 Effect of chronic Aegle marmelos fruit extract on insulinemic status in diabetic rats

From: Prevention of advanced glycation end-products formation in diabetic rats through beta-cell modulation by Aegle marmelos

Groups

Fasting serum insulin (pM)

Insulinogenic index (pM insulin/mM glucose)

β-cell function (%)

Day 1

Day 43

Day 1

Day 43

Day 1

Day 43

Control (n = 11)

170.3 ± 22.3

172.1 ± 27.5

37.21 ± 4.55

36.71 ± 3.72

136.25 ± 16.63

142.02 ± 21.38

Db (n = 8)

34.4 ± 1.72

27.5 ± 3.4

1.95 ± 1.13

1.60 ± 0.47

20.17 ± 3.57

11.54 ± 1.56

AM (n = 6)

39.5 ± 6.8

106.7 ± 12.0**

2.27 ± 0.62

10.76 ± 1.21**

21.07 ± 2.83

68.32 ± 4.56**

Gb (n = 6)

32.6 ± 6.8

87.7 ± 10.3*

2.17 ± 0.89

12.32 ± 1.06**

21.41 ± 3.11

74.85 ± 6.07**

  1. All values were expressed as mean ± SEM Control, non-diabetic control rats; Db, untreated diabetic rats; AM, Aegle marmelos-treated rats; Gb, glibenclamide-treated rats. Insulinogenic index: Insulin (pM) / glucose (mM). n = number of rats in each group. *p < 0.01, **p < 0.001, compared with Db values (one-way ANOVA with Dunnett’s multicomparison test)