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Table 3 Effects of SS on expression of protein metabolism related proteins

From: Saikosaponins induced hepatotoxicity in mice via lipid metabolism dysregulation and oxidative stress: a proteomic study

Protein name

protein ID

fold change

time(h)

protein description

Effect of SS on expression of translation related proteins

Sfrs5

O35326

1.24

4

Splicing factor, arginine/serine-rich 5

Sfrs7

Q8BL97

1.49

2

Splicing factor, arginine/serine-rich 7

Ptbp1

P17225

1.59

2

Polypyrimidine tract-binding protein 1

Ruxe

P62305

-1.38

24

Small nuclear ribonucleoprotein E

Smd2

P62317

-1.17

2

Small nuclear ribonucleoprotein Sm D2

Npm1

Q61937

-1.09

8

Nucleophosmin

Rps16

P14131

-2.29

8

40S ribosomal protein S16

Rpsa

P14206

-1.41

8

40S ribosomal protein SA

Rps14

P62264

-1.08

8

40S ribosomal protein S14

Rps24

P62849

-1.09

8

40S ribosomal protein S24

Rps28

P62858

-1.32

24

40S ribosomal protein S28

Rps19

Q9CZX8

-1.40

24

40S ribosomal protein S19

Effect of SS on expression of post-translation modification related proteins

Pmpcb

Q9CXT8

3.51

8

Mitochondrial-processing peptidase subunit beta

Hspa2

P17156

1.50

8

Heat shock-related 70 kDa protein 2

Hsp90ab1

P11499

-1.28

8

Heat shock protein HSP 90-beta

P4hb

P09103

-1.33

4

Protein disulfide-isomerase

Pdia3

P27773

-1.27

24

Protein disulfide-isomerase A3

Pdia6

Q922R8

-2.38

8

Protein disulfide-isomerase A6

Canx

P35564

-1.38

8

Calnexin

Erp44

Q9D1Q6

-1.91

8

Endoplasmic reticulum resident protein 44

Psmd14

O35593

1.37

8

26S proteasome non-ATPase regulatory subunit 14

Pmsa5

Q9Z2U1

1.53

4

Proteasome subunit alpha type-5

Psmb9

P28076

1.23

24

Proteasome subunit beta type-9

  1. Fold change: peak fold change of certain protein expression
  2. Time(h): time point after SS administration when reach peak fold change
  3. All fold changes are relative to Control group (time point 0 h)