Fig. 5
From: Effects of a combination treatment of KD5040 and L-dopa in a mouse model of Parkinson’s disease
Effects of combination treatment on ENK expression in the GPe. Immunohistochemical analyses of ENK expression in the GP (a, b). Western blot analyses of ENK expression in the GP (c, d). The MPTP group showed higher ENK immunoreactivity in the GPe, but combination treatment reduced ENK expression in the GP. C: control, M: MPTP, K: KD5040, LL: low dose of l -dopa (5 mg/kg), ML: medium dose of l -dopa (10 mg/kg). *** p < 0.001 vs. control, ### p < 0.001 vs. MPTP, and †† p < 0.01 vs. each dose of L-dopa. Error bars represent SEM. Scale bar: 200 μm. ENK: enkephaline; GPe: external segment of globus pallidus