Fig. 13
From: Effects of a combination treatment of KD5040 and L-dopa in a mouse model of Parkinson’s disease
Effects induced by l -dopa in the striatal MSNs of the direct pathway. a MPTP plus a high dose of L-dopa (20 mg/kg) not only replaced dopamine in terms of excessive concentrations but also overactivated the D1 receptor to cause hyperactivity in the direct striatonigral pathway. b Combination treatment resulted in a significant normalization of the D1 pathway, resulting in antidyskinetic effects. MSNs: medium spiny neurons