Fig. 12
From: Effects of a combination treatment of KD5040 and L-dopa in a mouse model of Parkinson’s disease
Basal ganglia motor circuits in normal (a), PD (b), and combination treatment (c) groups. Two families of receptors, D1 and D2, mediate the actions of dopamine in the basal ganglia. The progressive loss of dopaminergic neurons in the SNc causes PD and results in an imbalance of activities between the direct and indirect pathways. However, combination treatment enhanced motor function by correcting the imbalanced activity between the indirect and direct pathways in the basal ganglia. GP: globus pallidus, STN: subthalamic nucleus, GPi: internal globus pallidus, SNr: substantia nigra pars reticulate, SNc: substantia nigra pars compacta, PD: Parkinson’s disease