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Table 1 Significantly regulated KEGG pathways in TC-71 cells treated 24 h with viscumTT, viscum or TT versus untreated control cells

From: Transcriptomic and proteomic insight into the effects of a defined European mistletoe extract in Ewing sarcoma cells reveals cellular stress responses

Extract

Functional annotation

# Genes

p-Value

FDR

ViscumTT

MAPK signalling pathway

15

6.84 × 10^-6

6.70 × 10^-4

Positive regulation of cell death

15

1.54 × 10^-4

1.54 × 10^-2

Toll-like receptor signalling pathway

8

3.24 × 10^-4

1.58 × 10^-2

Oxidative stress response

6

1.06 × 10^-3

1.95 × 10^-2

Apoptosis

19

4.41 × 10^-5

2.84 × 10^-2

Viscum

Response to reactive oxygen species

8

2.59 × 10^-6

1.35 × 10^-3

Response to organic substance

19

2.17 × 10^-5

7.49 × 10^-3

Positive regulation of cell death

12

8.81 × 10^-4

7.34 × 10^-2

MAPK signalling pathway

10

1.75 × 10^-3

1.43 × 10^-1

TT

Toll-like receptor signalling pathway

3

4.86 × 10^-2

7.64 × 10^-1

Positive regulation of cell death

5

4.52 × 10^-2

9.95 × 10^-1

Inflammatory response

5

1.79 × 10^-2

1.00 × 10^+0

  1. *p ≤ 0.05 and FDR ≤ 0.1 regarded as significant