Table 2 Serum biochemistry profiles of (A) male and (B) female mice at the end of subacute toxicity dosing of K. galanga Linn. rhizome extract (1000, 3000, and 5000Â mg/kg body weight) and untreated control mice. Data are presented as median (95% CI)
Control | Â | K. galanga Linn. rhizome extract (mg/kg body weight) | ||
|---|---|---|---|---|
| Â | Â | 1000 | 3000 | 5000 |
A | ||||
 BUN (mg/dl) | 18.7 (15.8–21.54) | 22.0 (15.4–28.6) | 23.5 (19.71–27.29) | 28.3 (21.09–35.41)* |
 Creatinine (mg/dl) | 0.13 (0.10–0.27) | 0.23 (0.14–0.61) | 0.20 (0.20–0.20) | 0.20 (0.07–0.33) |
 Total protein (g/dl) | 4.70 (4.45–4.95) | 4.77 (4.48–5.05) | 5.62 (4.37–6.88) | 5.05 (4.75–5.36) |
 Albumin (g/dl)) | 3.03 (2.89–3.18) | 2.90 (2.65–3.15) | 3.15 (2.46–3.84) | 3.00 (2.78–3.23) |
 AST (U/l) | 57.0 (27.2–86.8) | 97.0 (20.5–173.5) | 109.5 (26.7–192.3) | 87.8 (59.7–115.8) |
 ALT (U/l) | 39.0 (21.6–56.4) | 53.3 (27.9–134.6) | 68.5 (11.5–148.5) | 56.5 (38.3–74.7) |
 ALP (U/l) | 90.0 (85.0–95.0) | 79.0 (57.5–101) | 68.5 (51.5–85.5) | 77.3 (54.4–100.1) |
 Sodium (mEq/L) | 150.3 (144.1–156.6) | 150.3 (140.9–159.7) | 149.5 (143.3–155.7) | 150.5 (146.5–154.5) |
 Potassium (mEq/L) | 11.5 (9.9–13.2) | 10.7 (5.6–15.9) | 13.7 (8.9–18.5) | 12.9 (10.8–15.0) |
 Cholesterol (mg/dl) | 113.0 (100.6–125.4) | 109.0 (95.17–122.8) | 153.7 (69.27–238.2) | 126.3 (108.2–144.3) |
 Triglycerides (mg/dl) | 81.00 (31.32–130.7) | 135.3 (83.15–187.5) | 242.3 (68.70–415.8) | 207.0 (147.9–266.0) |
 HDL (g/dl) | 113.0 (110.5–115.5) | 99.67 (83.70–115.6) | 137.8 (67.01–208.5) | 125.0 (94.48–155.5) |
 LDL (mg/dl) | 12.0 (9.5–14.5) | 9.7 (4.5–14.8) | 13.5 (4.3–22.7) | 9.0 (4.7–13.3) |
B | ||||
 BUN (mg/dl) | 19.25 (15.07–23.43) | 22.33 (20.9–23.77) | NA | NA |
 Creatinine (mg/dl) | 0.15 (0.06–0.24) | 0.13 (0.01–0.27) | NA | NA |
 Total protein (g/dl) | 4.55 (4.27–4.83) | 4.63 (4.01–5.26) | NA | NA |
 Albumin (g/dl)) | 3.13 (3.05–3.21) | 3.20 (2.95–3.45) | NA | NA |
 AST (U/l) | 56.75 (49.83–63.67) | 92.33 (78.65–106.01)* | NA | NA |
 ALT (U/l) | 23.25 (16.71–29.79) | 23.67 (2.54–44.79) | NA | NA |
 ALP (U/l) | 101.75 (83.78–119.72) | 97.33 (86.13–108.53) | NA | NA |
 Sodium (mEq/L) | 150.75 (148.03–153.47) | 151.03 (151.00–151.06) | NA | NA |
 Potassium (mEq/L) | 8.45 (6.14–10.77) | 8.40 (7.90–8.90) | NA | NA |
 Cholesterol (mg/dl) | 66.75 (51.58–81.92) | 69.67 (18.74–120.60) | NA | NA |
 Triglycerides (mg/dl) | 94.50 (60.96–120.04) | 117.33 (88.46–136.21) | NA | NA |
 HDL (g/dl) | 67.00 (53.56–80.44) | 63.00 (18.29–107.71) | NA | NA |
 LDL (mg/dl) | 8.50 (5.19–11.81) | 10.00 (2.55–17.45) | NA | NA |