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Table 1 Haematological profiles of (A) male and (B) female mice at the end of subacute toxicity dosing of K. galanga Linn. rhizome extract (1000, 3000, and 5000 mg/kg body weight) and untreated control mice. Data are presented as median (95% CI)

From: Anticholangiocarcinoma activity and toxicity of the Kaempferia galanga Linn. Rhizome ethanolic extract

Control

K. galanga Linn. rhizome extract (mg/kg body weight)

1000

3000

5000

A

 Red blood cells (×106/μl)

7.31 (6.16–8.46)

8.13 (6.90–9.36)

8.11 (7.59–8.62)

7.92 (7.49–8.35)

 Hemoglobin (g/dl)

12.27 (9.83–14.71)

12.80 (11.48–14.11)

13.03 (12.38–13.67)

12.43 (12.03–12.82)

 Hematocrit (%)

34.7 (29.5–39.8)

42.0 (37.7–46.3)

43.5 (37.5–49.5)*

41.8 (40.9–42.6)

 MCV

47.1 (46.19–47.94)

51.17 (46.48–55.86)

53.85 (45.19–62.51)

52.80 (50.46–55.13)

 MCH (pg)

16.8 (15.73–17.80)

15.77 (14.00–17.53)

16.10 (14.69–17.51)

15.73 (14.99–16.45)

 MCHC (g/dl)

35.6 (32.89–38.37)

30.8 (30.21–31.46)*

30.0 (27.48–32.52)*

29.8 (28.66–30.84)*

 White blood cells (×103/μl)

5.30 (1.02–9.58)

3.91 (3.30–4.53)

5.38 (3.98–6.79)

3.63 (2.90–4.35)

 Platelets (×105/μl)

6.29 (1.73–10.85)

10.67 (7.08–14.27)

7.43 (2.94–11.92)

6.53 (1.03–13.02)

B

 Red blood cells (×106/l)

7.59 (4.95–10.22)

6.92 (3.78–13.88)

NA

NA

 Hemoglobin (g/dl)

13.44 (11.89–14.99)

12.60 (8.85–16.35)

NA

NA

 Hematocrit (%)

37.80 (24.50–51.10)

34.00 (20.47–54.53)

NA

NA

 MCV

49.82 (48.83–50.82)

49.43 (40.10–58.76)

NA

NA

 MCH (pg)

19.06 (11.39–26.73)

18.20 (7.01–29.39)

NA

NA

 MCHC (g/dl)

38.22 (23.21–53.23)

36.53 (13.32–59.75)

NA

NA

 White blood cells (×103/μl)

3.66 (1.03–6.28)

4.15 (2.78–5.53)

NA

NA

 Platelets (×105/μl)

4.36 (0.91–7.81)

3.03 (0.44–6.05)

NA

NA

  1. *Significantly different from the control group, p = 0.01, 0.23, and 0.21 for the dose levels of 1000, 3000 and 5000 mg/kg body weight, respectively NA, data not available due to death or small sample. No statistical significant difference (p > 0.05) for the parameters evaluated between the treatment groups and control group