Phytochemical analysis with free radical scavenging, nitric oxide inhibition and antiproliferative activity of Sarcocephalus pobeguinii extracts

Table 3 Cytotoxic activity (LC₅₀ and IC₅₀ in μg/mL) and the selectivity index (SI) of extracts from roots, fruits, bark and leaves of Sarcocephalus pobeguinii and reference drug (doxorubicin) against cancer cell lines

Cell lines	Vero	MCF-7		HeLa		Caco-2		A549
Cell lines	LC₅₀ (μg/mL)	IC₅₀ (μg/mL)	SI	IC₅₀ (μg/mL)	SI	IC₅₀ (μg/mL)	SI	IC₅₀ (μg/mL)	SI
RSP	>1000	557.75 ± 60.35	nd	175.50 ± 31.37	nd	>1000	nd	857.25 ± 63.55	nd
FSP	601.42 ± 4.42	453.27 ± 6.41	1.32	194.81 ± 9.39	3.08	721.03 ± 68.35	0.83	>1000	nd
BSP	215.76 ± 10.83^a	70.23 ± 0.99	3.07	15.26 ± 0.45^a	14.13	62.65 ± 3.30^a	3.44	92.21 ± 0.91	2.33
LSP	186.30 ± 5.42^a	26.94 ± 1.15^a	6.91	10.19 ± 0.31^a	18.28	59.02 ± 2.37^a	3.15	50.46 ± 1.65^a	3.69
Doxorubicin (μM)	4.85 ± 0.29^b	1.78 ± 0.39^b	2.72	1.92 ± 0.29^b	2.52	3.00 ± 0.24^b	1.61	1.05 ± 0.67^b	4.61

nd not determined, LC ₅₀ concentration which is lethal to 50% of the cells compared to untreated controls, IC ₅₀ concentration required to inhibit the cell growth by 50% compared to untreated controls, LSP Methanol extract from leaves of S. pobeguinii, RSP Methanol extract from roots of S. pobeguinii, FSP CH₂Cl₂/MeOH (1:2) extract from fruits of S. pobeguinii, BSP Methanol extract from bark of S. pobeguinii
Data are presented as means of triplicate measurements ± standard error
^a significant difference between the extracts tested, (p ˂ 0.05)
^b significant difference between the extracts and the positive control, (p ˂ 0.05)

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