Skip to main content
Fig. 1 | BMC Complementary and Alternative Medicine

Fig. 1

From: Daily administration of yokukansan and keishito prevents social isolation-induced behavioral abnormalities and down-regulation of phosphorylation of neuroplasticity-related signaling molecules in mice

Fig. 1

Experimental schedule. a The therapeutic procedure: ISO and oral drug administration were started at the age of 3 and 5 week-old and continued during the experimental period. The 3-chamber sociability test (i), water-finding test (ii), and fear conditioning test (iii) were conducted at the age of 8, 9, and 11 week-old, respectively. b The preventive/delaying procedure: ISO and oral drug administration were started from at the age of 4 week-old and continued during the experimental period. The 3-chamber sociability test (i), water-finding test (ii), and fear conditioning test (iii) were conducted at the age of 6, 7, and 9 week-old, respectively. c The pharmacological analysis of preventive/delaying effect: ISO and oral drug administration were started at the age of 4 week-old and continued during the experimental period. The 3-chamber sociability test (i) and water-finding test (ii) were conducted at the age of 6 and 8 week-old, respectively. Animals were decapitated at 12 (a and b) or 8 (c) week-old, after completing all of the behavioral experiments

Back to article page

BMC Complementary Medicine and Therapies

ISSN: 2662-7671

Contact us