Fig. 1From: Alpinia oxyphylla Miq. fruit extract activates IGFR-PI3K/Akt signaling to induce Schwann cell proliferation and sciatic nerve regenerationThe regeneration of dissected sciatic nerves in the chambers filled with AOF. Sprague-Dawley rats weighing 220 ± 20 g underwent silicone chamber placement. The chambers in the right legs were filled with various concentrations of AOF as indicated. The sciatic nerves from the chamber in rats with surgery were taken. As shown by western blot analyses, AOF treatment upregulated PCNA, cyclin A, cyclin E (a) and the IGF-1, p-Akt, Bcl-XL (b) in a dose-dependent manner. α-tubulin was used as a loading controlBack to article page