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Table 2 Antibiotic resistance modulatory activity of R. heudelotii at sub-inhibitory concentrations against P. aeruginosa PA124

From: Antibacterial and antibiotic resistance modulatory activities of leaves and bark extracts of Recinodindron heudelotii (Euphorbiaceae) against multidrug-resistant Gram-negative bacteria

Plant extractsa Extract concentrationsb Antibioticsc and minimal inhibitory concentration (μg/mL)
CHL AMP ERY KAN TET CIP
  0 64 - 128 128 16 32
RHL MIC/2 32 (2) - 64(2) 64 (2) 4 (4) 32 (1)
MIC/4 32 (2) - 128 (1) 64 (2) 8 (2) 32 (1)
MIC/8 32 (2) - 128 (1) 64 (1) 8 (2) 32 (1)
MIC/16 64 (1) - 128 (1) 64 (1) 16 (1) 32 (1)
RHB MIC/2 64 (1) - 128 (1) 128 (1) 8 (2) 32 (1)
MIC/4 64 (1) - 128 (1) 128 (1) 16 (1) 32 (1)
MIC/8 64 (1) - 128 (1) 128 (1) 16 (1) 32 (1)
MIC/16 64 (1) - 128 (1) 128 (1) 16 (1) 32 (1)
  1. a: Recinodindronheudelotii, leaves (RHL); barks (RHB).b : MIC Minimal Inhibitory Concentration c: TET tetracycline, KAN kanamycin,, ERY erythromycin, CHL chloramphenicol, CIP ciprofloxacin, AMP ampicillin; −: MIC not detected at up to 256 μg/mL; (): Modulating factor; Values in bold represent the modulating factor ≥ 2