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Table 2 Antibiotic resistance modulatory activity of R. heudelotii at sub-inhibitory concentrations against P. aeruginosa PA124

From: Antibacterial and antibiotic resistance modulatory activities of leaves and bark extracts of Recinodindron heudelotii (Euphorbiaceae) against multidrug-resistant Gram-negative bacteria

Plant extractsa

Extract concentrationsb

Antibioticsc and minimal inhibitory concentration (μg/mL)

CHL

AMP

ERY

KAN

TET

CIP

 

0

64

-

128

128

16

32

RHL

MIC/2

32 (2)

-

64(2)

64 (2)

4 (4)

32 (1)

MIC/4

32 (2)

-

128 (1)

64 (2)

8 (2)

32 (1)

MIC/8

32 (2)

-

128 (1)

64 (1)

8 (2)

32 (1)

MIC/16

64 (1)

-

128 (1)

64 (1)

16 (1)

32 (1)

RHB

MIC/2

64 (1)

-

128 (1)

128 (1)

8 (2)

32 (1)

MIC/4

64 (1)

-

128 (1)

128 (1)

16 (1)

32 (1)

MIC/8

64 (1)

-

128 (1)

128 (1)

16 (1)

32 (1)

MIC/16

64 (1)

-

128 (1)

128 (1)

16 (1)

32 (1)

  1. a: Recinodindronheudelotii, leaves (RHL); barks (RHB).b : MIC Minimal Inhibitory Concentration c: TET tetracycline, KAN kanamycin,, ERY erythromycin, CHL chloramphenicol, CIP ciprofloxacin, AMP ampicillin; −: MIC not detected at up to 256 μg/mL; (): Modulating factor; Values in bold represent the modulating factor ≥ 2