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Table 1 Antiviral activity of the crude extracts of P. chinense against influenza viruses in the CPE reduction assay

From: Characterization and mechanisms of anti-influenza virus metabolites isolated from the Vietnamese medicinal plant Polygonum chinense

Sample

CC50 a

EC50 b (S.I.c)

Unit

PR8d

HKe

Leef

MeOH extract

> 300.0

55.0 (> 5.5)

38.4 (> 7.8)

55.5 (> 5.4)

μg/mL

Water layer

> 300.0

175.8 (>1.7)

68.5 (> 4.4)

212.1 (> 1.4)

μg/mL

BuOH layer

> 300.0

45.9 (> 6.5)

18.3 (> 16.4)

70.1 (> 4.3)

μg/mL

EtOAc layer

> 300.0

46.9 (> 6.4)

23.2 (> 13.0)

50.8 (> 5.9)

μg/mL

OSV-Cg

> 100.0

0.38 (> 263.2)

0.005 (> 20,000)

1.2 (> 83.3)

μM

RBVh

> 100.0

49.9 (> 2.0)

20.5 (> 4.9)

26.6 (>3.8)

μM

  1. aCC50, 50% cell toxicity concentration; bEC50, 50% effective concentration; cS.I., selectivity index = CC50/EC50; dPR8, A/Puerto Rico/8/34 (H1N1); eHK, A/Hong Kong/8/68 (H3N2); fLee, B/Lee/40; gOSV-C, oseltamivir carboxylate; hRBV, ribavirin