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Table 4 Anti-plasmodial activity of Norcaesalpin D and fractions from C. bonducella roots

From: Anti-plasmodial activity of Norcaesalpin D and extracts of four medicinal plants used traditionally for treatment of malaria

Fraction/Compound Antiplasmodial activity
IC50 ± SD (μg/mL)
Cytotoxicity CC50 ± SD (μg/mL) Selectivity index (SI) against IPC-4912
3D7 Dd2 IPC 4912 Mondolkiri Cambodia 2011 CC50 on LLC-MK2 (μg/mL ± SD)
1:1 DCM/EtoAC fraction 4.08 ± 2.87 9.33 ± 2.09 2.99 ± 4.84 76.09 ± 8.44 25.4
Sub-fraction 1 (Semi-pure) 3.06 ± 0.80 2.26 ± 0.97 5.12 ± 1.0 > 200 >39.1
Norcaesalpin D compound 0.98 ± 0.03
(2.83 μM)
1.85 ± 0.05
(5.35 μM)
2.13 ± 0.7
(6.16 μM)
> 200
(>578 μM)
>93.9
QN 0.052 ± 0.01 0.06 ± 0.01 0.068 ± 0.005   
  1. 1:1 DCM/EtoAC =1:1 dichloromethane/ethyl acetate fraction of dichloromethane root extract of C. bonducella; Sub-fraction 1 = column fraction of 1:1 DCM/EtoAC fraction; Norcaesalpin D isolated from sub-fraction1