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Table 4 Anti-plasmodial activity of Norcaesalpin D and fractions from C. bonducella roots

From: Anti-plasmodial activity of Norcaesalpin D and extracts of four medicinal plants used traditionally for treatment of malaria

Fraction/Compound

Antiplasmodial activity

IC50 ± SD (μg/mL)

Cytotoxicity CC50 ± SD (μg/mL)

Selectivity index (SI) against IPC-4912

3D7

Dd2

IPC 4912 Mondolkiri Cambodia 2011

CC50 on LLC-MK2 (μg/mL ± SD)

1:1 DCM/EtoAC fraction

4.08 ± 2.87

9.33 ± 2.09

2.99 ± 4.84

76.09 ± 8.44

25.4

Sub-fraction 1 (Semi-pure)

3.06 ± 0.80

2.26 ± 0.97

5.12 ± 1.0

> 200

>39.1

Norcaesalpin D compound

0.98 ± 0.03

(2.83 μM)

1.85 ± 0.05

(5.35 μM)

2.13 ± 0.7

(6.16 μM)

> 200

(>578 μM)

>93.9

QN

0.052 ± 0.01

0.06 ± 0.01

0.068 ± 0.005

  
  1. 1:1 DCM/EtoAC =1:1 dichloromethane/ethyl acetate fraction of dichloromethane root extract of C. bonducella; Sub-fraction 1 = column fraction of 1:1 DCM/EtoAC fraction; Norcaesalpin D isolated from sub-fraction1