Anti-plasmodial activity of Norcaesalpin D and extracts of four medicinal plants used traditionally for treatment of malaria

Table 3 In vitro antiplasmodial activity of fractions from H. pubescens methanolic root extract

Fraction	Antiplasmodial activity IC₅₀ ± SD (μg/mL)				Cytotoxicity CC₅₀ ± SD (μg/mL) LLC-MK2 cells
Fraction	3D7	K1	IPC 5202 Battambang- Cambodia 2011	IPC 4912 Mondolkiri- Cambodia 2011	Cytotoxicity CC₅₀ ± SD (μg/mL) LLC-MK2 cells
Fraction HPRM- 5	3.14 ± 0.18	5.23 ± 0.03	11.46 ± 0.2	8.61 ± 0.97	>200
Fraction HPRM- 7	1.20 ± 0.35	2.18 ± 0.95	2.52 ± 1.8	5.95 ± 2.79	>200
QN	0.052 ± 0.01	0.060 ± 0.01	0.074 ± 0.0	0.068 ± 0.005	>200

HPRM-5 40% ethyl acetate/petroleum ether column fraction of H. pubescens methanolic root extract, HPRM-7 70% ethyl acetate/petroleum ether column fraction of H. pubescens methanolic root extract, QN quinine

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