Samples | Brine shrimp cytotoxicity (μg/ml) | Cytotoxicity against leishmanial promastigotes (μg/ml) | THP-1 cytotoxicity (μg/ml) | Protein kinase inhibition (μg/disc) | ||||
---|---|---|---|---|---|---|---|---|
 | % Mortality | LC50 | % Mortality | IC50 (μg/mL) | % Mortality | IC50 | *Diameter (mm) at 100 μg/disc | |
 | 200 |  | 100 |  | 10 |  | Clear zone | Bald zone |
Leaf | ||||||||
 n-hex | 100 ± 4.10 | 36.7 ± 0.56 | 98.2 ± 3.12 | 15.78 ± 0.77 | -- | -- | 7 ± 0.51 | -- |
 CHCl3 | 98 ± 3.11 | 38.5 ± 0.65 | 90.7 ± 3.05 | 18 ± 0.18 | 64.2 ± 0.71 | 7.8*** ± 0.61 | 6 ± 0.62 | -- |
 Acet | 96 ± 3.00 | 52.2 ± 0.66 | 95.3 ± 3.18 | 21.60 ± 0.25*** | 26.1 ± 0.10 | >10 | __ | 9 ± 0.7 |
 Acet + EtOAc | 92 ± 2.75 | 58.7 ± 0.71*** | 75 ± 1.19 | 35.43 ± 0.41 | 61.9 ± 0.71 | 8.1** ± 0.71 | 8 ± 0.73 | -- |
 EtOAc | 86 ± 1.31 | 64.5 ± 0.78 | 72 ± 1.22 | 64.50 ± 0.62** | -- | -- | -- | 6 ± 0.56 |
 EtOH | 82 ± 1.16 | 62.7 ± 0.81** | 66.4 ± 0.75 | 75.40 ± 1.17 | -- | -- | -- | 12.5 ± 1.71*** |
 MeOH | 65 ± 0.75 | 86.2 ± 1.18e | 63.6 ± 0.66 | 81.60 ± 1.12 | 40.4 ± 0.61 | >10 | -- | 13.5 ± 1.11*** |
 MeOH+ CHCl3 | 67 ± 0.71 | 88.1 ± 1.51 | 69.3 ± 0.80 | 77.75 ± 1.23* | 35.7 ± 0.21 | >10 | -- | 11 ± 0.87** |
 EtOH+ CHCl3 | 62 ± 0.72 | 87.9 ± 1.30 | 54.6 ± 0.57 | 97.8 ± 3.11* | -- | -- | -- | 11 ± 0.88** |
 EtOH + EtOAc | 68 ± 0.81 | 82.3 ± 1.11* | 68.2 ± 0.77 | 57.41 ± 0.75 | -- | -- | 6.5 ± 0.11 | -- |
 MeOH + EtOAcet | 57 ± 0.55 | 93.2 ± 1.75 | 72.7 ± 1.01 | 54.55 ± 0.71 | -- | -- | 6.6 ± 0.12 | -- |
Stem | ||||||||
 n-hex | 100 ± 4.13 | 39.6 ± 0.65 | 62.6 ± 0.80 | 75.74 ± 1.10** | -- | -- | 8 ± 0.75 | -- |
 CHCl3 | 98 ± 2.16 | 43.9 ± 0.56b | 52.8 ± 0.56 | 78.72 ± 1.19 | 54.7 ± 0.71 | 8.4** ± 0.72 | 9.5 ± 0.98 | -- |
 Acet | 87 ± 1.33 | 55.1 ± 0.60* | 48.1 ± 0.46 | >100 | 52.3 ± 0.70 | 8.9* ± 0.88 | 6.5 ± 0.65 | -- |
 Acet + EtOAc | 76 ± 1.18 | 62.7 ± 0.77*** | 46.6 ± 0.41 | >100 | -- | -- | 6.5 ± 0.66 | -- |
 EtOAc | 78 ± 1.19 | 59.5 ± 0.56** | 49.2 ± 0.51 | >100 | -- | -- | 8 ± 0.85 | -- |
 EtOH | 72 ± 1.15 | 64.4 ± 0.68 | 56.7 ± 0.80 | 97.73 ± 3.15*** | -- | -- | 7.5 ± 0.62 | -- |
 MeOH | 75 ± 1.17 | 68.7 ± 0.71** | 52.2 ± 0.90 | 95.58 ± 1.10 | -- | -- | -- | 12.5 ± 1.12*** |
 MeOH+ CHCl3 | 62 ± 0.72 | 68.3 ± 0.72 | 28.4 ± 0.07 | >100 | 16.6 ± 0.11 | >10 | -- | 8 ± 0.66 |
 EtOH+ CHCl3 | 45 ± 0.09 | >200 | 26.7 ± 0.05 | >100 | -- | -- | -- | 10 ± 0.75** |
 EtOH + EtOAc | 42 ± 0.07 | >200 | 18.7 ± 0.08 | >100 | -- | -- | -- | 9 ± 0.96 |
 MeOH + EtOAc | 48 ± 0.07 | >200 | 14.4 ± 0.07 | >100 | -- | -- | 7 ± 0.70 | -- |
 Doxorubicin | 100 ± 4.10 | 5.75 ± 0.07 |  |  |  |  |  |  |
 Flourouracil |  |  |  |  | 99.6 ± 4.19 | 5.1 ± 0.11 |  |  |
 Vincristine |  |  |  |  | 98.1 ± 3.17 | 8.1 ± 0.92 |  |  |
 Surfactin |  |  |  |  |  |  |  | 17 ± 1.02 |
 Amphotercin-B |  |  | 100 ± 4.01 | 1.36 ± 0.11 |  | -- | -- | -- |
 1% DMSO in PBS/sea water | -- |  | -- |  | -- |  |  |  |
 DMSO |  |  |  |  |  |  |  | -- |