|
Test materials
|
Concentration producing Vmax
|
%Vmax without phentolamine
|
%Vmax with phentolamine (1 μM)
|
|---|
|
POL4.Cr
|
10 (mg/ml)
|
55 ± 2.88
|
27.5 ± 2.50###
|
|
Ci.Cr
|
3 (mg/ml)
|
33.66 ± 7.53**
|
Blocked###
|
|
Gs.Cr
|
3 (mg/ml)
|
113 ± 3.51***
|
76.66 ± 3.33###
|
|
Ns.Cr
|
5 (mg/ml)
|
80.33 ± 2.60**
|
18.33 ± 4.41###
|
|
Tfg.Cr
|
Did not exhibited any vasoconstriction
|
|
Verapamil
|
Did not exhibited any vasoconstriction
|
|
P.E
|
1 (μM)
|
75.19 ± 2.16 ***
|
Blocked###
|
- Data represents mean ± SEM of 4 to 8 experiments
-
Abbreviations: POL
4
.Cr the crude extract of poly herbal formulation, Ci.Cr the crude extract of C. intybus, Gs.Cr the crude extract of G. sylvestre, Ns.Cr the crude extract of N. sativa, Tfg.Cr the crude extract of T. foenum graecum, P.E Phenylephrine
- ns, non-significant, **p < 0.01 and ***/###
p < 0.001
- * shows a comparison of %Vmax of test materials without phentolamine vs. POL4.Cr (One-way ANOVA followed by Dunnett’s test), while # shows a comparison between %Vmax values without phentolamine vs. respective %Vmax values with phentolamine (Unpaired t-test)
