Pharmacological basis for the medicinal use of polyherbal formulation and its ingredients in cardiovascular disorders using rodents

Table 4 Percentage maximum vasoconstriction (%V_max) of test materials without and with phentolamine in rat aortic tissues

Test materials	Concentration producing V_max	%V_max without phentolamine	%V_max with phentolamine (1 μM)
POL₄.Cr	10 (mg/ml)	55 ± 2.88	27.5 ± 2.50^###
Ci.Cr	3 (mg/ml)	33.66 ± 7.53**	Blocked^###
Gs.Cr	3 (mg/ml)	113 ± 3.51***	76.66 ± 3.33^###
Ns.Cr	5 (mg/ml)	80.33 ± 2.60**	18.33 ± 4.41^###
Tfg.Cr	Did not exhibited any vasoconstriction
Verapamil	Did not exhibited any vasoconstriction
P.E	1 (μM)	75.19 ± 2.16 ***	Blocked^###

Data represents mean ± SEM of 4 to 8 experiments
Abbreviations: POL ₄ .Cr the crude extract of poly herbal formulation, Ci.Cr the crude extract of C. intybus, Gs.Cr the crude extract of G. sylvestre, Ns.Cr the crude extract of N. sativa, Tfg.Cr the crude extract of T. foenum graecum, P.E Phenylephrine
ns, non-significant, **p < 0.01 and ***/^### p < 0.001
* shows a comparison of %V_maxof test materials without phentolamine vs. POL₄.Cr (One-way ANOVA followed by Dunnett’s test), while ^# shows a comparison between %V_max values without phentolamine vs. respective %V_maxvalues with phentolamine (Unpaired t-test)

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