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Table 4 Percentage maximum vasoconstriction (%Vmax) of test materials without and with phentolamine in rat aortic tissues

From: Pharmacological basis for the medicinal use of polyherbal formulation and its ingredients in cardiovascular disorders using rodents

Test materials Concentration producing Vmax %Vmax without phentolamine %Vmax with phentolamine (1 μM)
POL4.Cr 10 (mg/ml) 55 ± 2.88 27.5 ± 2.50###
Ci.Cr 3 (mg/ml) 33.66 ± 7.53** Blocked###
Gs.Cr 3 (mg/ml) 113 ± 3.51*** 76.66 ± 3.33###
Ns.Cr 5 (mg/ml) 80.33 ± 2.60** 18.33 ± 4.41###
Tfg.Cr Did not exhibited any vasoconstriction
Verapamil Did not exhibited any vasoconstriction
P.E 1 (μM) 75.19 ± 2.16 *** Blocked###
  1. Data represents mean ± SEM of 4 to 8 experiments
  2. Abbreviations: POL 4 .Cr the crude extract of poly herbal formulation, Ci.Cr the crude extract of C. intybus, Gs.Cr the crude extract of G. sylvestre, Ns.Cr the crude extract of N. sativa, Tfg.Cr the crude extract of T. foenum graecum, P.E Phenylephrine
  3. ns, non-significant, **p < 0.01 and ***/### p < 0.001
  4. * shows a comparison of %Vmax of test materials without phentolamine vs. POL4.Cr (One-way ANOVA followed by Dunnett’s test), while # shows a comparison between %Vmax values without phentolamine vs. respective %Vmax values with phentolamine (Unpaired t-test)