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Table 3 Effects of 80ME and solvent fractions of the leaves of Myrtus communis L on gastrointestinal fluid accumulation in mice

From: Evaluation of the antidiarrheal activity of the leaf extracts of Myrtus communis Linn (Myrtaceae) in mice model

Dose (mg/kg) Volume of intestinal contents (ml) % inhibition Weight of intestinal contents (gm) % inhibition
Control 0.86 ± 0.07 ------- 1.12 ± 0.03 -------
80ME 100 0.64 ± 0.04a2b1f1 25.58 0.91 ± 0.05a2b1f1 18.75
80ME 200 0.53 ± 0.03a3 38.37 0.77 ± 0.06a3 31.25
80ME 400 0.46 ± 0.02a3 46.51 0.70 ± 0.02a3 37.50
Loperamide 3 0.47 ± 0.04a3 45.35 0.71 ± 0.03a3 36.61
Control 0.78 ± 0.08 -------- 1.02 ± 0.07 --------
CF 200 0.61 ± 0.07b1 21.79 0.85 ± 0.07b1 16.67
CF 300 0.53 ± 0.04a1 32.05 0.75 ± 0.04a1 26.47
CF 400 0.48 ± 0.04a2 38.46 0.69 ± 0.03a2 32.35
Loperamide 3 0.43 ± 0.06a2 44.87 0.66 ± 0.05a3 35.29
Control 0.83 ± 0.06 ----- 1.10 ± 0.03 -------
MF 200 0.67 ± 0.04b1 19.28 0.93 ± 0.07b1 15.45
MF 300 0.58 ± 0.03a1 30.12 0.81 ± 0.04a1 26.36
MF 400 0.49 ± 0.08a2 40.96 0.73 ± 0.08a2 33.64
Loperamide 3 0.47 ± 0.04a3 43.47 0.68 ± 0.02a3 38.18
Control 0.83 ± 0.06 ------ 1.10 ± 0.03 -------
AF 200 0.76 ± 0.04b2g1j1n1 8.43 1.02 ± 0.05b3g2j2n1 8.18
AF 300 0.73 ± 0.07b1j1n1 12.05 0.98 ± 0.07b2g1j1 10.91
AF 400 0.68 ± 0.07 18.07 0.93 ± 0.05b1 15.45
AF 800 0.55 ± 0.02a2 33.74 0.76 ± 0.03a2 30.90
Loperamide 0.47 ± 0.04a3 43.47 0.68 ± 0.02a3 38.18
  1. Values are mean ± SEM (n = 6); analysis was performed using one way ANOVA followed by Tuckey post hoc test; a compared with control values; b compared with loperamide; c compared with 100 mg/kg; d compared with 200 mg/kg; ecompared with 300 mg/kg; f compared with 400 mg/kg; g compared with 800 mg/kg, h compared with CF200, i compared with CF300, j compared with CF400, kcompared with MF200, m compared with MF 300, n compared with MF 400; 1 p < 0.05, 2 p < 0.01, 3 p < 0.001; 80ME = 80% methanol extract, CF = chloroform fraction, MF = methanol fraction, AF = aqueous fraction. Controls are 10 ml/kg- distilled water (for 80ME, MF and AF) and 2% Tween-80 (for CF)