Evaluation of the antidiarrheal activity of the leaf extracts of Myrtus communis Linn (Myrtaceae) in mice model

Table 3 Effects of 80ME and solvent fractions of the leaves of Myrtus communis L on gastrointestinal fluid accumulation in mice

Dose (mg/kg)	Volume of intestinal contents (ml)	% inhibition	Weight of intestinal contents (gm)	% inhibition
Control	0.86 ± 0.07	-------	1.12 ± 0.03	-------
80ME 100	0.64 ± 0.04^a2b1f1	25.58	0.91 ± 0.05^a2b1f1	18.75
80ME 200	0.53 ± 0.03^a3	38.37	0.77 ± 0.06^a3	31.25
80ME 400	0.46 ± 0.02^a3	46.51	0.70 ± 0.02^a3	37.50
Loperamide 3	0.47 ± 0.04^a3	45.35	0.71 ± 0.03^a3	36.61
Control	0.78 ± 0.08	--------	1.02 ± 0.07	--------
CF 200	0.61 ± 0.07^b1	21.79	0.85 ± 0.07^b1	16.67
CF 300	0.53 ± 0.04^a1	32.05	0.75 ± 0.04^a1	26.47
CF 400	0.48 ± 0.04^a2	38.46	0.69 ± 0.03^a2	32.35
Loperamide 3	0.43 ± 0.06^a2	44.87	0.66 ± 0.05^a3	35.29
Control	0.83 ± 0.06	-----	1.10 ± 0.03	-------
MF 200	0.67 ± 0.04^b1	19.28	0.93 ± 0.07^b1	15.45
MF 300	0.58 ± 0.03^a1	30.12	0.81 ± 0.04^a1	26.36
MF 400	0.49 ± 0.08^a2	40.96	0.73 ± 0.08^a2	33.64
Loperamide 3	0.47 ± 0.04^a3	43.47	0.68 ± 0.02^a3	38.18
Control	0.83 ± 0.06	------	1.10 ± 0.03	-------
AF 200	0.76 ± 0.04^b2g1j1n1	8.43	1.02 ± 0.05^b3g2j2n1	8.18
AF 300	0.73 ± 0.07^b1j1n1	12.05	0.98 ± 0.07^b2g1j1	10.91
AF 400	0.68 ± 0.07	18.07	0.93 ± 0.05^b1	15.45
AF 800	0.55 ± 0.02^a2	33.74	0.76 ± 0.03^a2	30.90
Loperamide	0.47 ± 0.04^a3	43.47	0.68 ± 0.02^a3	38.18

Values are mean ± SEM (n = 6); analysis was performed using one way ANOVA followed by Tuckey post hoc test; ^a compared with control values; ^b compared with loperamide; ^c compared with 100 mg/kg; ^d compared with 200 mg/kg; ^ecompared with 300 mg/kg; ^f compared with 400 mg/kg; ^g compared with 800 mg/kg, ^h compared with CF200, ⁱ compared with CF300, ^j compared with CF400, ^kcompared with MF200, ^m compared with MF 300, ⁿ compared with MF 400; ¹ p < 0.05, ² p < 0.01, ³ p < 0.001; 80ME = 80% methanol extract, CF = chloroform fraction, MF = methanol fraction, AF = aqueous fraction. Controls are 10 ml/kg- distilled water (for 80ME, MF and AF) and 2% Tween-80 (for CF)

ISSN: 2662-7671