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Table 2 Effects of 80ME and solvent fractions of the leaves of Myrtus communis L on gastrointestinal transit in mice

From: Evaluation of the antidiarrheal activity of the leaf extracts of Myrtus communis Linn (Myrtaceae) in mice model

Dose (mg/kg) Length of small intestine (cm) Distance moved by the charcoal meal (cm) Peristaltic index (%) % inhibition
Control 56.17 ± 1.42 36.67 ± 1.94 65.09 ± 2.25 -------
80ME 100 58.33 ± 0.80 25.17 ± 2.43a3b2f2 43.26 ± 4.37a3b2f2 33.54
80ME 200 58.67 ± 1.12 20.05 ± 1.09a3 35.07 ± 2.27a3 46.12
80ME 400 58.17 ± 2.01 14.33 ± 1.65a3 24.53 ± 2.53a3 62.31
Loperamide 3 56.33 ± 1.28 14.83 ± 0.91a3 26.29 ± 1.34a3 59.61
Control 57.67 ± 1.76 36.17 ± 4.18 62.33 ± 6.06 ------
CF 200 56.33 ± 1.08 25.17 ± 3.46b1 44.88 ± 6.39b1 27.99
CF 300 59.50 ± 1.09 24.00 ± 1.39a1 40.44 ± 2.60a1 35.11
CF 400 60.17 ± 1.89 20.67 ± 2.43a2 34.37 ± 3.91a2 44.86
Loperamide 3 56.83 ± 1.11 14.00 ± 1.41a3 24.58 ± 2.32a3 60.56
Control 58.50 ± 0.67 36.83 ± 3.21 62.81 ± 5.11 -------
MF 200 59.17 ± 1.38 29.17 ± 1.96b2 49.47 ± 3.47b2 21.24
MF 300 59.50 ± 1.41 24.00 ± 3.33a1 40.29 ± 5.48a1 35.85
MF 400 59.00 ± 1.59 19.17 ± 3.27a3 32.95 ± 5.99a3 47.54
Loperamide 3 56.33 ± 1.28 13.67 ± 1.52a3 24.20 ± 2.55a3 61.47
Control 58.50 ± 0.67 36.83 ± 3.21 62.81 ± 5.11 ------
AF 200 56.83 ± 0.95 34.00 ± 1.83b3g1j1n1 59.79 ± 2.98b3g1j1n2 4.81
AF 300 56.83 ± 1.92 31.00 ± 2.05b2g1 54.91 ± 4.33b2g1n1 12.58
AF 400 59.17 ± 0.98 29.50 ± 3.09b2 49.79 ± 4.95b2 20.73
AF 800 56.83 ± 1.17 21.83 ± 3.55a2 38.56 ± 6.29a2 38.61
Loperamide 3 56.33 ± 1.28 13.67 ± 1.52a3 24.20 ± 2.55a3 61.47
  1. Values are mean ± SEM (n = 6); analysis was performed using one way ANOVA followed by Tuckey post hoc test; a compared with control values; b compared with loperamide; c compared with 100 mg/kg; d compared with 200 mg/kg; ecompared with 300 mg/kg; f compared with 400 mg/kg; g compared with 800 mg/kg; h compared with CF200; i compared with CF300; j compared with CF400; kcompared with MF200; m compared with MF 300; n compared with MF 400; 1 p < 0.05, 2 p < 0.01, 3 p < 0.001; 80ME = 80% methanol extract, CF = chloroform fraction, MF = methanol fraction, AF = aqueous fraction. Controls received 10 ml/kg- distilled water (for 80ME, MF and AF) and 2% Tween-80 (for CF)