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Table 4 Effect of aqueous and methanol extracts of Piptadeniastrum africanum on serum parameters in CFA-induced arthritis in rats

From: Anti-arthritic property of crude extracts of Piptadeniastrum africanum (Mimosaceae) in complete Freund’s adjuvant-induced arthritis in rats

  Dose (mg/kg) CRP (mg/l) RF (IU/ml) ALP (U/l) ALT (U/l) AST (U/l) Total protein (g/dl)
Healthy control - 1.69 ± 0.01 - 71.67 ± 2.73 44.73 ± 2.60 41.33 ± 1.86 6.69 ± 0.58
Arthritic control - 6.92 ± 0.24γ 58.00 ± 1.53 471.00 ± 13.23 186.53 ± 11.93γ 132.67 ± 4.10γ 4.83 ± 0.12β
Indomethacin 5 3.84 ± 0.30γc 40.33 ± 1.86c 204.33 ± 46.04βc 123.29 ± 4.41γc 101.67 ± 1.76γc 5.85 ± 0.45α
Aqueous extract 200 6.11 ± 0.32γ 51.67 ± 1.76 416.33 ± 14.33γ 153.76 ± 8.69γa 125.09 ± 2.65γ 5.01 ± 0.07
400 3.98 ± 0.05γc 40.00 ± 1.54c 340.07 ± 26.15γb 121.67 ± 2.03γc 113.77 ± 7.88γa 5.38 ± 0.25
Methanol extract 200 4.29 ± 0.19γc 40.33 ± 0.88c 214.13 ± 4.67γc 119.19 ± 1.45γc 93.33 ± 3.48γc 5.53 ± 0.10
400 3.04 ± 0.04βc 31.00 ± 1.16c 131.60 ± 5.24c 82.21 ± 6.66αc 74.56 ± 5.78γc 6.40 ± 0.26a
  1. CFA complete Freund’s adjuvant, CRP C-reactive protein, RF rheumatoid factor, ALP alkaline phosphatase, AST aminotransferase, ALT alanine aminotransferase. Each value represents the mean ± ESM for six animals and analyses by two-way ANOVA followed by Tukey post-hoc test, α P < 0.05, β P < 0.01, γ P < 0.001 when compared to healthy control, a P < 0.05, b P < 0.01, c P < 0.001 when compared to arthritic control